@ @
Group A-7 ‰»Šw\‘’@(Chemical Structure)  
œ p-Aminosalicylic acid i‚o‚`‚rjip-ƒAƒ~ƒmƒTƒŠƒ`ƒ‹Ž_j
@
CAS: 65-49-6 @Medicine @MW: 153.14

REC E. coli Min( 10 mg/plate; }S9)
›
1)
1) Leifer Z., et al.: Mutation Res., 87, 211-297 (1981) (a review)
œ Amitrole iƒAƒ~ƒgƒ[ƒ‹j (3-ƒAƒ~ƒm-1H-1,2,4-ƒgƒŠƒAƒ][ƒ‹j@
@@@
61-82-5@Pesticide/Herbicide@84.08@ @
AM Sal. Max ( 10 mg/plate; }S9)
 
1,2)
YM Yeast Max (1000 ppm)(mitotic gene conversion)
 
3,4)
DNA B.subtilis (DNA Repair) Max (?)
 
5)
MB E.coli (pol A test) ; Max (?)
 
6)
YM Yeast (Mitotic Gene Conversion Test); Max (?)
 
3)
SM Human LY Max (?)
 
7)
SLRL Drosophila Max (?)
 
8)
MB Mice (Host-Mediated Assay); Max ( 250-1585 mg/kg, im or po)
 
9)
DL Mice Max ( 1000 mg/kg, po)
 
1)
SPM Mice Max ( 500 mg/kg, ip)
 
10)
CA Mice
Bone Marrow
Max ( 10 ppm, fed)
 
1)
DNA Mice
Germ Cells
(DNA-damage); Max ( 1000 mg/kg, po)
 
11)
1) Deutsche Forschungsgemeinschaft: VCH Verlagsgesellschaft mbH, Weinheim, FRG (1983)
2) Andersen KJ. et al.: J. Agric. food Chem., 20, 649-656 (1972)
3) Siebert D. & Lemperle E.: Mutation Res. 22, 110-120 (1974)
4) Simmon VF: J. Natl Cancer Inst., 62, 901-909 ( 1979)
5) Shirasu Y. et al.: Mutation Res., 40, 19-30 (1976)
6) Rosenkranz HS. & Pirier LA.: J. Natl Cancer Inst., 62, 873-892 (1979)
7) Meretoja T. et al.: Mutation Res., 40, 191-196 (1976)
8) Laamanen I., et al.: Mutation Res., 40, 185-190 (1976)
9) Simmon VF. et al.: J. Natl Cancer Inst., 62, 911-918( 1979)
10) Topham JC: Mutation Res., 74, 379-387 (1980)
11) Seller JP: Mutation Res. 46, 305-310 (1977)

US-NTP Genotoxicity ScreeningF
›@Ames Test:
 
›@CA Test:
 
›@SCETest:
›
›@MLA Test:
 
›@Drosophila (SLRL)Test:
 

IARC Carcinogenicity CriteriaFGroup 2B

yNotez(Cited from IARC Monographs, Suppl., 6, 1987)
@No data were available on the genetic and related effects of amitrole in humans.
@It did not induce MNs in bone-marrow cells of mice or UDS in hepatocytes of rats treated in vivo. It induced transformation of Sy. hamster embryo cells and increased the incidence of SCEs in CHO cells; both positive and negative results were reported for mutation in cultured rodent cells. It did not induce SLRL mutation or aneuploidy in Drosophila; it induced CAs in plants. Both positive and negative results were obtained in assays for gene conversion and mutation in fungi, but it induced aneuploidy. It was not mutagenic to bacteria and did not induce DNA damage. (IARC Monographs, 7, 31, 1974; 41, 293, 1986).

œ Ammonium bicarbonate id’YŽ_ƒAƒ“ƒ‚ƒjƒEƒ€j
@
1066-33-7  Food@ 79.06
AM Sal Max (5 mg/plate ; }S9)
 
1)
CA CHL/IU Max (0.5 mg/ml ; -S9), 24h
 
2)
1) Ishidate MJr. et al: (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro, LIC, Tokyo (1998j (Tables in English)
œ Ammonium hydroxide (aqueous 25% solution)i…Ž_‰»ƒAƒ“ƒ‚ƒjƒEƒ€j
@
1336-21-6 @Industry/Food@228.19
CA CHL/IU Max ( 0.5 mg/ml; -S9), 24h
 
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro LIC, Tokyo (1998j (Tables in English)
     œ Ammonium pentaborate iƒzƒEŽ_ƒAƒ“ƒ‚ƒjƒEƒ€A‚P‰–Šξj
@@@@  
12007-89-5@Industry@544.29
AM Sal./E.coli Max( 5 mg/plate;}S9)
 
1)
1) Ministry of Labour, Japan: Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996) (Tables in English)
œ Ammonium persulfate@i‰ί—°Ž_ƒAƒ“ƒ‚ƒjƒEƒ€j
@
  7727-54-0@@Industry/Food@@228.19@@
AM Sal./E.coli Max( 10 mg/plate, }S9)   1)
CA CHL/IU Max( 0.25 mg/ml, -S9), 24-48h
 
2)
1) Ishidate MJr, et al., Mutagenecity & Toxicity, Vol. 4, 5 10-19 (1981)
2) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro LIC, Tokyo (1998j (Tables in English)
@
@@
œ Ammonium phosphate, monobasic i—ΣŽ_ƒAƒ“ƒ‚ƒjƒEƒ€A‚P‰–Šξj
@  7722-76-1@Food @115.03

CA CHL/IU Min ( 1.5 mg/ml; -S9), 48h
›
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test in vitro. LIC, Tokyo (1998j (Tables in English)

œ p-Ammonium tungstate (p-ƒ^ƒ“ƒOƒXƒeƒ“Ž_ƒAƒ“ƒ‚ƒjƒEƒ€j
@@@@
11120-25-5@Industry@3132.62
AM Sal/E.coli Max( 5 mg/plate;}S9)
 
1)
1) Ministry of Labour, Japan: Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996)(Tables in English)

œ DL-Amphetamine sulfate (Alentol)iƒAƒŒƒ“ƒg[ƒ‹j@
@ 
60-13-9@@Medicine@368.49

AM Sal Max( 5 mg/plate;}S9)
 
1)
CA CHL/IU Max( 0.25 mg/ml ; -S9), 48h
 
2)
1) ?
2) Sofuni T. (Ed.): Data Book of Chromosome@Aberration Test In vitro, LIC, Tokyo (1998j (Tables in English)

œ ƒΐ-Amylase@(sweet potato)@iƒΐ-ƒAƒ~ƒ‰[ƒ[j
@@
9000-91-3@@ Food/Natural @@`152,000

CA CHL/IU Max( 1.0 mg/ml ; -S9), 24-48h
 
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test in vitro LIC, Tokyo (1998j (Tables in English)

œ
N-Amyl-N'-nitroguanidine@iN-ƒAƒ~ƒ‹-N-ƒjƒgƒƒOƒAƒjƒWƒ“j

@ 
35089-69-1@Laboratory@174.20

AM Sal. Max( 5 mg/plate;}S9)
 
1)
CA CHL/IU Max( 0.25 mg/ml ; -S9), 24-48h
 
2)
1) Ishidate MJr. et al: : Natl Inst. Hygien. Sci., ?
2) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)
@@@

œ N-Amyl-N'-nitro-N-nitrosoguanidine  iN-ƒAƒ~ƒ‹-N'-ƒjƒgƒ-N-ƒjƒgƒƒ\ƒOƒAƒjƒWƒ“j iANNGj
@ 
 61-82-5@@Laboratory@84.08
@@@
AM Sal. Min ( 5 mg/plate;}S9)
›
1)
CA CHL/IU Min ( 0.03 mg/ml ; -S9), 24h;@D20= 0.019; TR= 1200

2)

1) Ishidate MJr & Odashima S: , Mutation Res., 48, 337-354 (1977)
2) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro, LIC, Tokyo (1998j (Tables in English)

œ N-Amyl-N-nitrosourethane iN-ƒAƒ~ƒ‹l-N-ƒjƒgƒƒ\ƒEƒŒƒ^ƒ“j
@@
@64005-62-5@@ Laboratory@@188.23

AM Sal. Max (?)
 
1)
CA CHL/IU Min ( 0.0158 mg/ml ; -S9), 24h;@D20= 0.031; TR= 630

2)
1) Ishidate MJr & Odashima S: , Mutation Res., 48, 337-354 (1977)
2) Sofuni T. (Ed.): Data Book of Chromosomal@Aberration Test In vitro,LIC, Tokyo (1998j(Tables in English)

œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity i•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj