A-7

　　

Group A-7 化学構造　(Chemical Structure)

● p-Aminosalicylic acid （ＰＡＳ）（p-アミノサリチル酸）
　 CAS: 65-49-6 　Medicine 　MW: 153.14

REC E. coli Min( 10 mg/plate; ±S9) ○ 1)

1) Leifer Z., et al.: Mutation Res., 87, 211-297 (1981) (a review)

● Amitrole （アミトロール） (3-アミノ-1H-1,2,4-トリアゾール）　
　　　61-82-5　Pesticide/Herbicide　84.08　　

AM Sal. Max ( 10 mg/plate; ±S9) □ 1,2)

YM Yeast Max (1000 ppm)(mitotic gene conversion) □ 3,4)

DNA B.subtilis (DNA Repair) Max (?) □ 5)

MB E.coli (pol A test) ; Max (?) □ 6)

YM Yeast (Mitotic Gene Conversion Test); Max (?) □ 3)

SM Human LY Max (?) □ 7)

SLRL Drosophila Max (?) □ 8)

MB Mice (Host-Mediated Assay); Max ( 250-1585 mg/kg, im or po) □ 9)

DL Mice Max ( 1000 mg/kg, po) □ 1)

SPM Mice Max ( 500 mg/kg, ip) □ 10)

CA Mice
Bone Marrow Max ( 10 ppm, fed) □ 1)

DNA Mice
Germ Cells (DNA-damage); Max ( 1000 mg/kg, po) □ 11)

1) Deutsche Forschungsgemeinschaft: VCH Verlagsgesellschaft mbH, Weinheim, FRG (1983)
2) Andersen KJ. et al.: J. Agric. food Chem., 20, 649-656 (1972)
3) Siebert D. & Lemperle E.: Mutation Res. 22, 110-120 (1974)
4) Simmon VF: J. Natl Cancer Inst., 62, 901-909 ( 1979)
5) Shirasu Y. et al.: Mutation Res., 40, 19-30 (1976)
6) Rosenkranz HS. & Pirier LA.: J. Natl Cancer Inst., 62, 873-892 (1979)
7) Meretoja T. et al.: Mutation Res., 40, 191-196 (1976)
8) Laamanen I., et al.: Mutation Res., 40, 185-190 (1976)
9) Simmon VF. et al.: J. Natl Cancer Inst., 62, 911-918( 1979)
10) Topham JC: Mutation Res., 74, 379-387 (1980)
11) Seller JP: Mutation Res. 46, 305-310 (1977)

US-NTP Genotoxicity Screening：
○　Ames Test: □
○　CA Test: □
○　SCETest: ○
○　MLA Test: □
○　Drosophila (SLRL)Test: □

IARC Carcinogenicity Criteria：Group 2B

【Note】(Cited from IARC Monographs, Suppl., 6, 1987)

　No data were available on the genetic and related effects of amitrole in humans.
　It did not induce MNs in bone-marrow cells of mice or UDS in hepatocytes of rats treated in vivo. It induced transformation of Sy. hamster embryo cells and increased the incidence of SCEs in CHO cells; both positive and negative results were reported for mutation in cultured rodent cells. It did not induce SLRL mutation or aneuploidy in Drosophila; it induced CAs in plants. Both positive and negative results were obtained in assays for gene conversion and mutation in fungi, but it induced aneuploidy. It was not mutagenic to bacteria and did not induce DNA damage. (IARC Monographs, 7, 31, 1974; 41, 293, 1986).

● Ammonium bicarbonate （重炭酸アンモニウム）
　 1066-33-7 Food　 79.06

AM Sal Max (5 mg/plate ; ±S9) □ 1)

CA CHL/IU Max (0.5 mg/ml ; -S9), 24h □ 2)

1) Ishidate MJr. et al: (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro, LIC, Tokyo (1998） (Tables in English)

● Ammonium hydroxide (aqueous 25% solution)（水酸化アンモニウム）
　 1336-21-6 　Industry/Food　228.19

CA CHL/IU Max ( 0.5 mg/ml; -S9), 24h □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro LIC, Tokyo (1998） (Tables in English)

● Ammonium persulfate　（過硫酸アンモニウム）
　 7727-54-0　　Industry/Food　　228.19　　

AM Sal./E.coli Max( 10 mg/plate, ±S9) □ 1)

CA CHL/IU Max( 0.25 mg/ml, -S9), 24-48h □ 2)

1) Ishidate MJr, et al., Mutagenecity & Toxicity, Vol. 4, 5 10-19 (1981)
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro LIC, Tokyo (1998） (Tables in English)
　　　
● Ammonium phosphate, monobasic （燐酸アンモニウム、１塩基）
　 7722-76-1　Food 　115.03

CA CHL/IU Min ( 1.5 mg/ml; -S9), 48h ○ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test in vitro. LIC, Tokyo (1998） (Tables in English)

● p-Ammonium tungstate (p-タングステン酸アンモニウム）
　　　　11120-25-5　Industry　3132.62

AM Sal/E.coli Max( 5 mg/plate;±S9) □ 1)

1) Ministry of Labour, Japan: Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.) (1996)(Tables in English)

● DL-Amphetamine sulfate (Alentol)（アレントール）　
　 60-13-9　　Medicine　368.49

AM Sal Max( 5 mg/plate;±S9) □ 1)

CA CHL/IU Max( 0.25 mg/ml ; -S9), 48h □ 2)

1) ?
2) Sofuni T. (Ed.): Data Book of Chromosome　Aberration Test In vitro, LIC, Tokyo (1998） (Tables in English)

● β-Amylase　(sweet potato)　（β-アミラーゼ）
　　9000-91-3　　 Food/Natural 　　～152,000

CA CHL/IU Max( 1.0 mg/ml ; -S9), 24-48h □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test in vitro LIC, Tokyo (1998） (Tables in English)

● N-Amyl-N'-nitroguanidine　（N-アミル-N-ニトログアニジン）
　 35089-69-1　Laboratory　174.20

AM Sal. Max( 5 mg/plate;±S9) □ 1)

CA CHL/IU Max( 0.25 mg/ml ; -S9), 24-48h □ 2)

1) Ishidate MJr. et al: : Natl Inst. Hygien. Sci., ?
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)
　　　
● N-Amyl-N'-nitro-N-nitrosoguanidine （N-アミル-N'-ニトロ-N-ニトロソグアニジン）（ANNG）
　 61-82-5　　Laboratory　84.08
　　　

AM Sal. Min ( 5 mg/plate;±S9) ○ 1)

CA CHL/IU Min ( 0.03 mg/ml ; -S9), 24h;　D20= 0.019; TR= 1200 ◎ 2)

1) Ishidate MJr & Odashima S: , Mutation Res., 48, 337-354 (1977)
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro, LIC, Tokyo (1998） (Tables in English)

● N-Amyl-N-nitrosourethane （N-アミルl-N-ニトロソウレタン）
　　　64005-62-5　　 Laboratory　　188.23

AM Sal. Max (?) □ 1)

CA CHL/IU Min ( 0.0158 mg/ml ; -S9), 24h;　D20= 0.031; TR= 630 ◎ 2)

1) Ishidate MJr & Odashima S: , Mutation Res., 48, 337-354 (1977)
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In vitro,LIC, Tokyo (1998）(Tables in English)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity （変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal.	Max ( 10 mg/plate; ±S9)	□	1,2)
YM	Yeast	Max (1000 ppm)(mitotic gene conversion)	□	3,4)
DNA	B.subtilis	(DNA Repair) Max (?)	□	5)
MB	E.coli	(pol A test) ; Max (?)	□	6)
YM	Yeast	(Mitotic Gene Conversion Test); Max (?)	□	3)
SM	Human LY	Max (?)	□	7)
SLRL	Drosophila	Max (?)	□	8)
MB	Mice	(Host-Mediated Assay); Max ( 250-1585 mg/kg, im or po)	□	9)
DL	Mice	Max ( 1000 mg/kg, po)	□	1)
SPM	Mice	Max ( 500 mg/kg, ip)	□	10)
CA	Mice Bone Marrow	Max ( 10 ppm, fed)	□	1)
DNA	Mice Germ Cells	(DNA-damage); Max ( 1000 mg/kg, po)	□	11)

AM	Sal	Max (5 mg/plate ; ±S9)	□	1)
CA	CHL/IU	Max (0.5 mg/ml ; -S9), 24h	□	2)

AM	Sal./E.coli	Max( 10 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max( 0.25 mg/ml, -S9), 24-48h	□	2)

AM	Sal	Max( 5 mg/plate;±S9)	□	1)
CA	CHL/IU	Max( 0.25 mg/ml ; -S9), 48h	□	2)

AM	Sal.	Min ( 5 mg/plate;±S9)	○	1)
CA	CHL/IU	Min ( 0.03 mg/ml ; -S9), 24h;　D20= 0.019; TR= 1200	◎	2)