| 選択した化合物の種類 （ List of The Compounds Selected ) |
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| 選択した化合物の種類 （ List of The Compounds Selected ) |
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| 国内外で変異原性試験（遺伝毒性試験）が行われた約2000種類の化合物を選択した。この中には、医薬品をはじめ、食品添加物、農薬、化粧品、医療用品およびその他の工業用化学物質のほか、天然物も含まれている。 化合物はアルファベット順に並べ、便宜上、幾つかのグループに分けた。原則として、一般名を使用したが、可能な限り別名も添付した。検索する化合物を含むグループをクリックすると、それらのデータベースが表示される。 表の右側には、本データベースから得られた結果をもとに、変異原性の有無を定性的に色分けして表示した。また、合わせて、IARCによる発がん性の評価の分類を表示した。（略記号のファイルを参照のこと） 化合物の種類は、主として、下記の文献から選択した。いずれも、専門誌あるいは文書によって既に公開されたものである。（他のデーターベースについては、情報のファイルを参考のこと） 各化合物は、CAS番号のファイルから検索可能であるが、個々の化合物ではなく、化合物のグループにリンクされている。また、化合物の構造式はデータベース内から検索可能である。 |
| Nearly 2000 compounds including industrial chemicals or natural substances, used for medical drugs, food additives, pesticides, cosmetics of which mutagenicity data were published in scientfic documents during about past 20 years, have been selected. They were alphabetically arranged in several groups with their CAS Numbers. Additonal information is noted in the last 2 items; a qualitative evaluation of the genotoxicity data extracted from this database, and evaluation of carciogenic activities of the compound on which the IARC has been classified.(See Abbreviation) Please click the group of compounds in which your target chemical is included. You can find the chemical group also from the list of CAS numbers . |
| No | Papers or Documents | Contents (Test systems+) |
| 1 | American Conference of Governmental Industrial Hygienists, Inc. (ACGIH): Threshold Limit Values or Chemical Substances in the Work Environment (1997) | Industrial chemicals |
| 2 | Anderson B et al., Environ. Mol Mutagen., 16 (Suppl. 18), 55-137 (1990) | 42 chemicals (CA, SCE)* |
| 3 | Ashby J. & Tennant RW., Ditection of rodent carcinogens for 44 chemicals: results: Mutagenesis, 9, 7-15 (1994) | 44 chemcals * |
| 4 | Brown JP & Dietrich PS: Mutation Res., 66, 223-240 (1979) | Plant flavonols (AM) |
| 5 | Bruce WR & Heddle JA: Can. J. Genet. Cytol., 21, 319-334 (1979): | 61 chemicals |
| 6 | CICADS (IPCS/WHO) (1998-2004) (a review) | 63 Industrial chemicals |
| 7 | Cagy Z., et al., .Acta Microbiol. Acad. Sci-Human Genetics, 22, 309-314 (1975) | Pesticides (AM) |
| 8 | De Flora S: Carcinogenesis, 2, 283-298 (1981) | 106 chemicals (AM) |
| 9 | De Serres, FJ. and Ashby J.: Evaluation of Short-Term Tests for Carcinogens, Prog.in Mutation Res.,1, Elsevier/North-Holland (1982) | 42 chemicals (AM etc.) |
| 10 | Dunkel VC. et al., Environ. Mutagen., 7 (Suppl. 5), 1-248 (1985) | Carciinogens & non-carcinogens (AM) |
| 11 | ECETOC Monograph, 27 (1997): | 73 chemicals (Aneu) |
| 12 | Foureman P. et al., Environ. Mol. Mutagen., 23, 51-63 (1994) | 50 chemicals (Drosophila) |
| 13 | Foureman P. et al., Environ. Mol. Mutagen., 23, 208-227 (1994) | 70 chemicals (Drosophila)* |
| 14 | Galloway SM et al., Environ. Mol., Mutagen.,10 (Suppl. 10), 1-176 (1987) | 108 chemicals (CA)* |
| 15 | Galloway SM et al., Environ. Mutagen.,7, 1-52 (1985) | 22 chemicals (CA)* |
| 16 | Gold, LS. and Zeiger, E ; Hand Book of Carcinogenic Potency and Genotoxicity Databases, CRC Press (1998) | 1475 chemicals (AM, CA, SCE, MLA, and Drosophila)* |
| 17 | Gulati DK., et al.,Environ. Mol. Mutagen., 13, 133-193 (1989) | 27 chemicals (CA, SCE)* |
| 18 | Haworth S et al., Environ. Mutagen., 5 (Suppl. 1) 3-142 (1983) | 250 chemicals (AM)(a) |
| 19 | Hayashi M, et al.: Fd. Chem. Toxic, 26, 487 (1988) | 39 food additives etc.(MNv) |
| 20 | Hude W., et al.: Mutation Res., 203, 81-94 (1988) | 124 chemicals (Chromo.Test) |
| 21 | IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl. 6. (1987) | 141 chemicals (a review) |
| 22 | Ishidate MJr and Odashima S.: Mutation Res., 48, 337 (1977) | 134 chemicals (CA) |
| 23 | Ishidate, MJr, et al.: Mutation Res., 195, 151-213 (1988) | 951 chemicals (CA: a review) |
| 24 | Ishidate MJr (Ed): Data Book for In Vitro Chromosomal Aberration Tests on Chemicals, LIC/Tokyo, Elsevier/Amsterdam (1988) | 400 chemicals (CA: Data Book) |
| 25 | Ishidate MJr (Ed): Data Book of Mutagenicity Tests on Chemicals in bacteria, LIC/Tokyo (1991) (Tables in English) | 535 chemicals (AM) |
| 26 | Ivett JL., et al., Environ. Mol. Mutagen, 14, 165-187 (1989) | 15 chemicals (CA, SCE)* |
| 27 | Kada T & Ishidate MJr: Data Book for Mutagenicity of Chemicals, Scientist/Tokyo (1980) | 1708 chemicals (Data Book) |
| 28 | Latt SA, et al., Mutation Res., 87, 17-62 (1981) | 195 chemicals (SCE) * |
| 29 | Loveday KS, et al.: Environ. Mol. Mutagen., 16, 272-303 (1990) | 40 chemicals (CA, SCE)* |
| 30 | Matsushita H (Ed): Data Book for Carcinogenicity & Mutagenicity of Chemicals, IPC/Tokyo (1983) | 100 chemicals (AM) |
| 31 | Matsuoka A.., et al., Mutation Res., 272, 223-236 (1992) | Miscellaoeus (MN in vitro) |
| 32 | McCann J, et al.: Proc. Natl Acad. Sci. (USA), 72, 5135-5139 (1975) | 300 chemicals (AM) |
| 33 | McGregor DB. et al., Environ. Mol. Mutagen., 11, 91-118 (1988) | 18 chemicals (MLA)* |
| 34 | McGregor DB. et al., Environ. Mol. Mutagen., 12, 85-154 (1988) | 72 chemicals (MLA)* |
| 35 | McGregor DB. et al., Environ. Mol. Mutagen., 17, 196-219 (1991) | 27 chemicals (MLA)* |
| 36 | McGregor DB. et al., Environ. Mol. Mutagen., 17, 122-129 (1991) | Gases & vapors (MLA) |
| 37 | Michell AD. et al., Environ. Mol. Mutagen., 12,(Suppl. 13), 37-102 (1988) | 63 chemicals (MLA)* |
| 38 | Ministry of Health, Labor & Welfare, Japan: Toxicity Testing Reports of Environmental Chemicals, Chemical Investigation Promoting Council (Ed.), Vol. 1-9 (1994-2002):(Tables in English) | 208 chemicals (AM, CA, or MNv) |
| 39 | Ministry of Labor, Japan; Mutagenicity Test Data of Exsisting Chemical Substances; JETOC (Ed.) (1996-2000) (Tables in English) | 375 chemicals (AM and/or CA) |
| 40 | Morita T, et al. : Mutation Res., 389, 3-122 (1997) | 43 carcinotens (MNv) |
| 41 | Mortelmans K., et al., Environ. Mutagen., 8 (Suppl. 7) 1-119 (1986) | 270 chemicals (AM)* |
| 42 | Mueller-Tegethoff, K., et al., Mutation Res., 335, 293-307 (1995) | (MN in vitro hepatocytes) |
| 43 | Muzzall JM & Cook WL: Mutation Res., 67, 1-8 (1979) | Cosmetic dyes (AM) |
| 44 | Myhr BC & Caspary WJ,, Environ. Mol. Mutagen., 12 (Supp.13) 103-194 (1988) | 63 chemicals (MLA)* |
| 45 | Myhr BC & Caspary WJ,, Environ. Mol. Mutagen., 18 51-83 (1991) | 31 chemicals (MLA)* |
| 46 | Myhr BC., et al., Environ. Mol. Mutagen., 16 (Suppl. 18), 138-169 (1990) | 41 chemicals (MLA)* |
| 47 | Nishioka H., Mutation Res., 31, 185-189 (1975) | 56 metal compounds (REC) |
| 48 | Oberly TJ., et al.: Mutation Res., 125, 291-306 (1984) | 42 chemicals (MLA) |
| 49 | Shelby MD. & Witt KL: Environ Mol. Mutagen., 1995, 25, 302-313 (1995) | (CAv & MNv) |
| 50 | Sofuni T. (Ed.): Data Book of Chromosome Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)) | 901 chemicals (CA) |
| 51 | Sofuni T., et al., Mutation Res., 241, 175-213 (1990) | 25 chemicals (CA) |
| 52 | Storer RD, et al., Alkaline elution/rat hepatocyte assay (DNA damage): Mutation Res., 368, 59-101 (1996) | Miscellaoeus (DNA) |
| 53 | Tucker JD et al., Sister-chromatid exchange: second report of the Gene-Tox Program: Mutat Res., Sepl. 297(2): 101-80 (1993) | Miscellaoeus(SCE) |
| 54 | Valencia R., et al.: Environ. Mutagen. 7, 325-348 (1985) | 48 chemicals (Drosophila) |
| 55 | Williams GM. et al., Mutation Res., 221, 263-286 (1989) | Miscellaoeus (DNA repair) |
| 56 | Woodruff RC., et al., Environ. Mutagen. 7, 677-702 (1985) | 53 chemicals (Drosophila)* |
| 57 | Yoon JS., et al., Environ. Mutagen. 7, 349-367 (1985) | 45 chemicals (Drosophila)* |
| 58 | Zeiger E, et al.: Environ. Mutagen. 6 (Suppl 9), 1-110 (1987) | 255 chemicals (AM) * |
| 59 | Zeiger E, et al.: Environ. Mutagen. 16 (Suppl., 18), 32-54 (1990) | 42 chemicals (AM) * |
| 60 | Zeiger E, et al.: Environ. Mol. Mutagen. 19 (Suppl., 21), 2-141 (1992) | 311 chemicals (AM) * |
| 61 | Zinmmering S., et al.: Environ. Mutagen. 7, 87-100 (1985) | 20 chemicals (Drosophila)* |
| 62 | Other scientific reports or documents | Not specified |