B-5

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

Group B-5 化学構造　(Chemical Structure)

● 5'-［bis(2-acetoxyethyl)amino-2'-(2-bromo-4,6-dinitrophenylazo)-4-methoxy- acetanilide
　　CAS: 3618-72-2　 Industry　 MW: 625.39

CA CHL/IU Min ( 0.015 mg/ml, -S9), 24h; D20= 0.016 ○ 1)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,4-Bis (aminoethyl) benzene
　　539-48-0　 Industry　 136.20

AM Sal /E.coli Min (1.25 mg/plate, +S9); Spa= 435 (TA104) ○ 1)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,3-Bis(aminomethyl) benzene　（1,3-(アミノメチル)ベンゼン） (n-Xylenediamine)
　 1477-55-0 　Industry 　 136.22

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1,2)

CA CHL/IU Max ( 0.47 mg/ml, ±S9). 6-18h □ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996)
(Tables in English)
2) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1997) (Tables in English)

● 1,4-Bis(aminopropyl) piperazine
　　7209-38-3 　Industry 　 200.33

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 3 (1996)(Tables in English)

Bis(1-bromo-2-propenyl) hydrogen phosphate （ビス(2-ブロモ-2-プロペニル)
　　36596-43-7 Industry 　 335.92

CA CHL/IU Max ( 4.0 mg/ml, -S9), 24h △ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In Vitro, LIC, Tokyo (1998)
(Tables in English)
　
● 1,1-Bis(tert-butyldioxy)-3,3,5-trimethylcyclohexane（1,1-(tert-ブチルジオキシ)-3,3,5-
トリメチルシクロヘキサン）
　　　6731-36-8 Industry 　 302.45

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 3.0 mg/ml, ±S9); 6-18h; □ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(2)(2001) (Tables in English)

● Bis(2-chloroethyl) ether 　(2,2'-Dichloroethyl ether)
　　　111-44-4 　Industry 　 143.01

AM Sal/E.coli Min ( 2.5 mg/ plate, -S9); ○ 1)

CA CHL/IU Min( 0.05 mg/ml,+S9), 6-18h; D20= 0.036; TR= 1000
Min( 0.75 mg/ml,-S9), 48h; Poly ○ 2)

HTAv Mice Max ( not specified), or ), for 8 w. □ 3)

1) Ministry of Labour, Japan: Mutagen. Test Data, Exist. Chem. Subst., Suppl., pp. 149 JETOC (ed.) (1997)(Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal　Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)
3) Jorgenson A et al., Mutation Res., 53, 124 (1978)

● N, N'-Bis(2-chloroethyl)-2-naphthylamin　 (Chlornaphazine)（クロロナファジン）
494-03-1 　Industry　 268.20

AM Sal Min ( 10.0 μg/plate, +S9) ○ 1)

1) McCann, J. et al.,: Proc. Natl. Acad. Sci.(USA), 72, 5135-5139 (1975)

● 1,3-Bis (2-chloroethyl)-1-nitrosourea (BCNU) （1,3-ビス(2-クロロエチル)-1-ニトロソ尿素）　
　　154-93-8 　Medicine　　 214.05

AM Sal/E.coli Min (?) ○ 1)

CA CHL/IU Min ( 0.0038 mg/ml, -S9), 24h; D20= 0.003; TR= 7200 ◎ 2)

1) Ishidate MJr, et al: Natl Inst. of Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Bis(2,3-dibromopropyl) magnesium phosphate （ビス(2,3-ジブロモプロピル）リン酸マグネシウム）
　　　36711-31-6　　Industry　　 1017.76

CA CHL/IU Min ( 2.0 mg/ml, -S9), 24h; D20= 3.4; TR= 4.0 ○ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998)
(Tables in English)

● Bis(dimethylthiocarbamoyl) disulfide (Thiram; TMTD, チラム）
　　137-26-8　　Agriculture/Industry　　 240.44

CA CHL/IU Max ( 0.0004 mg/ml, -S9), 6-18h; △ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● 4,4'-Bis(ethylcarbamoyl) diphenylmethane （4,4'-ビス(エチルカルバモイル)ジフェニルエタン）
　　Industry　　 314.38

CA CHL/IU Max ( 0.002 mg/ml, -S9), 6-18h
Min ( 0.0003 mg/ml, -S9), 24h; Poly △
○ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)

● 2,4-Bis(ethylcarbamoyl) toluene　（2,4-ビス(エチルカルバモイル) トルエン）
　　Industry　　 238.28

CA CHL/IU Max ( 0.4 mg/ml, ±S9), 24-48h □ 1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English

● 5'-［N,N-Bis［ (2-isobutoxycarbonyl) ethyl］amino］-4'-methoxy-2'-(5-nitro-2-
　thiazolylazo) acetanilide
　　82457-22-5　　Industry 　　 622.7

CA CHL/IU Min ( 0.013 mg/ml, -S9); 24h; Poly. PD20= 0.024 ○p 1)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)
　　　　
● Bis(1-methylethyl)naphthalene （ビス(1-メチルエチル)ナフタレン）
　　　38640-62-9 　 Industry 　 212.33

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 0.281 mg/ml, +S9); 6-18h; D20= 0.88 ○ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol.7 (1999)(Tables in English)

● Bis(1-methyl-1-phenylethyl) peroxide　（過酸化ビス(1-メチル-1-フェニルエチル))
　　80-43-3　 Industry 　 270.37

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max (　0.02 mg/ml, ±S9); 6-18h; □ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(1)(2001)(Tables in English)　　

● Bisphenol A （ビスフェノールA）　（2,2-Bis(4-hydroxydiphenyl)proane）
　　　80-05-7 　　Industry　　 228.29

AM Sal/E.coli Max (.0.625 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 0.1 mg/ml, -S9), 6-18h △ 2)

1) Ministry of Labour, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Bisphenol S （ビスフェノールS）　（Bis(4-hydroxyphenyl) sulfone）
　　80-09-1 　　Industry　　 250.3

AM Sal/E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

1) Ministry of Labor, Japan; Mutagen. Test Data of Exist. Chemi. Subst.; JETOC (Ed.), (1996) (Tables in English)

● 1,2-Bis(stearoylamino)ethane 　（1,2-ビス(ステアロイル)エタン）
　　 110-30-5 　Industry 　 593.02

AM Sal /E.coli Max ( 5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Max ( 0.5 mg/ml, ±S9); 6-18h; □ 1)

1) Ministry of Health & Welfare,Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 8(1)(2001) (Tables in English)

● Bitumens　（ビチューメン;　歴青）
　　 128683-24-9 Industry

【Note】 (Cited from IARC Monographs, Suppl., 6, 198７)

　Antigenicity against benzo(a)byrene diol epoxide-DNA adducts has been demonstrated in peripheral blood lymphocytes of roofers (1).
　Both an extract of road-surfacing bitumen and its emissions were mutagenic to Salmonella, whereas, in another study, 'asphalt tar' from an asphalt concrete used for road surfacing was not (2).
　Bitumen-based paints for pipe coating were not mutagenic to Salmonella (3).
　1) Shamsuddin, AKM et al., Cancer Res., 45, 66-68 (1985)
　2) Tamakawa, K et al., Sendai-shi Eisei Shikenshoho, 13, 246-257 (1983)
　3) Robinson, M et al., J. Appl. Toxicol., 4, 49-56 (1984)(IARC Monographs, 35, 39, 1985):

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity （変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal/E.coli	Max ( 5.0 mg/plate, ±S9)	□	1,2)
CA	CHL/IU	Max ( 0.47 mg/ml, ±S9). 6-18h	□	1)

AM	Sal/E.coli	Min ( 2.5 mg/ plate, -S9);	○	1)
CA	CHL/IU	Min( 0.05 mg/ml,+S9), 6-18h; D20= 0.036; TR= 1000 Min( 0.75 mg/ml,-S9), 48h; Poly	○	2)
HTAv	Mice	Max ( not specified), or ), for 8 w.	□	3)

AM	Sal/E.coli	Min (?)	○	1)
CA	CHL/IU	Min ( 0.0038 mg/ml, -S9), 24h; D20= 0.003; TR= 7200	◎	2)

AM	Sal/E.coli	Max (.0.625 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.1 mg/ml, -S9), 6-18h	△	2)

AM	Sal /E.coli	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 0.5 mg/ml, ±S9); 6-18h;	□	1)