People exposed occupationally to cadmium (in an alkaline-battery factory
and in the manufacture of cadmium pigments) did not exhibit increased frequencies
of CAs in their peripheral Lym. These findings contrast markedly with the
positive results obtained on workers exposed in zinc smelting plants and
on people environmentally intoxicated by cadmium; these people were also
exposed to other compounds (see IARC, 11,39; Leonard, 229, 1986). In one
study, SCEs were not induced in people exposed to cadmium in the environment
(Nogawa, Tsuritani, Yamada, 283, 1986).
Cadmium compounds did not produce DL effects in mice or rats nor did they increase the frequencies of CAs or MNs in mice treated in vivo. Cadmium compounds induced aneuploidy in hamsters but not in mice treated in vivo. They did not induce SCEs in human cells in vitro, and studies of CAs gave inconclusive results. They induced transformation of cultured rodent cells in several test systems and induced CAs but not SCEs in rodent cells in vitro.
They induced DNA single-strand breaks in human and rodent cells, and there is conflicting evidence that they produced mutation rodent cells in vitro. They did not induce aneuploidy or somatic or SLRL mutations in Drosophila. They induced mitotic recombination in yeast, but they did not induce
mutation in yeast or bacteria, nor did they induce prophage in bacteria.
(IARC Monographs, 2, 74; 11,39) |
