Group C-11

化学構造　(Chemical Structure)

● Copper (quinolin-8-olato) (コッパー）　　　　 　　
　　  10380-28-6　 Pesticide　 MW: 353.87

REC	B. subtilis	Max ( 50 μｇ/disk)	□	1)
AM	Sal.	Max ( 10 μｇ/plate)	□	1)
CA	CHL/IU	Max ( 0.136 mｇ/ml, -S9)	□	1)
MNv	Rat/CFY	Max ( 5.6 g/kg x 2)	□	1)

1) Nihon Noyaku Co. Ltd., et al: J. Pesticide Sci., 16, 563-567 (1991)

● Creatinine 　（クレアチニン）　　 　　
　　　 60-27-5 　Laboratory　 113.12

CA

CHL/IU

Min (10 mｇ/ml, -S9), 24h; D20= 8.0 mg/ml; TR= 1.5

○

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998） (Tables in English)

● p-Cresidine　（p-クレシジン） (2-Methoxy-5-methylaniline
　　　 120-71-8 　Industry　 137.18

AM	Sal./E. coli	Min ( 0.156 mg/plate, +S9) spa= 1040 (TA100)	○	1)
CA	CHL/IU	Min ( 0.10 mg/ml, -S9), 24h; D20= 0.20; TR= 98	○	2)
MNv	CD-1 mice	Max ( 2 ｇ/kg x 2 ,po), 24h;	□	3)

1) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) Suppl. pp. 217 (1997) (Tables in English)
2) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.), Suppl. 3,  pp. 222 (2005) (Tables in English)
3) MoritaT.,et al., Mutation Res., 389, 3-122 (1997)

● m-Cresol 　(3-Methylphenol) （m-クレゾール；　 ヒドロキシトルエン;　　クレゾール酸）
　　　 108-39-4　　Industry 　 108.14

AM	Sal./ E. coli	Max ( 1.25 mg/plate, ±S9)	□	1-3)
MLA	L5178Y	Max ( 0.5 mg/ml, ±S9)	□	4)
CA	CHO	Max (?), ±S9)	□	4)
UDS	Rat hepatocytes	Max ( 0.01 mg/ml, -S9)	□	4)
SCE	Human Fb..	Max (?), -S9)	□	5)
SCE	Human Ly.	Max (?), -S9)	□	6)
CT	Mouse 3T3	Max ( 72 nl/ml, ±S9)	□	7)
DNA	SV40 induction	Min (?,), -S9)	○w	8)
DNA	CH cells	Max (?,), -S9)	□	9)
SCEv	Mice, BM/Liver	Max ( 200 mg/kg, ip)	□	4)

1) Ministry of Labor, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) Suppl. (1997)  (Tables in English)
2) Douglas GR., et al., Water Chorinate. Environ. Impact. Health Effects, 3, 865-880 (1980)
3) Haworth S., et al., Environ. Mutagen., 1, 3-142 (1983)
4) Hazleton labs. Repl submitet to US-EPA (unpublished data) (1989)
5) Cheng M & Kligerman AP, Mutation Res., 137, 51-55 (1984)
6) Jansson T., et al., Mutation Res., 169,, 129-139 (1986)
7) Hazleton labs. Repl submitet to US-EPA (unpublished data) (1988)
8) Moor SP & Cochill TP, Prog. Nucleic Acid, Res. Mol. Biolol., 29, 149-153 (1983)
9) Pool BL., et al., Mutation Res., 213, 61-72 (1989)
10) UIS-NTP Reprot., 9, 1990/1991 (1990/1991)
11) Cheng M & Kligerman AP, Mutation Res., 137, 51-55 (1984)

● Crotonaldehyde (2-Butenal) （クロトンアルデヒド）
　　　 4170-30-3 　Industry 　 70.09

CA

CHL/IU

Min ( 0.003 mｇ/ml, -S9), 24;Poly also; D20=0.0025 TR=400

◎

1)

1) Ministry of Labour, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) (1996)

● Crotonaldehyde (trans-form) （クロトンアルデヒド トランス体）
　　　 123-73-9　 Industry 　 70.09

AM

Sal./ E. coli

Min ( 0.0781 mg/plate, -S9); Spa=2440 (TA100)

◎

1)

1) Ministry of Labor, Japan; Mutagen, Test Data of Exist. Chem.. Subst., JETOC (Ed.) (1996) (Tables in English)

● Cucumopine （ククモパイン）
　　　 110342-24-0 　Natural 　 283.24

CA

CHL/IU

Min ( 5.0 mｇ/ml, -S9), 48h; D20= 7.9; TR= 1.0 Poly ( 0.5 mg/ml, -S9), 48h; D20= 0.10

○

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998） (Tables in English)

● Cumene （クメン）（2-phenyl-propane; isopropylbenzene, 1-methylethyl-benzene）
　　 98-82-8 　Industry 　 120.2
　　　　54724-00-4 　　Food

UDS	Rat hepatocytes	Min ( 16μｇ/ml ）	○	1)
CT	BALB/3T3	Min ( 60 μｇ/ml ）	○	1)

1) Hazardous Substances Data Bank (HSDB), U.S. Natl Library of Medicine (1998)

【Note】　(Cited from CICADs Documents, 18, 1999)

In general, negative results have been obtained in a relatively complete battery of in vivo and in vitro mutagenicity tests, including gene mutation, chromosomal aberration, and primary DNA damage (US EPA, 1997). Cumene was tested at concentrations up to 2000 μg/plate in a Salmonella typhimurium reverse mutation assay (modified Ames test); negative results were observed with and without metabolic activation (Lawlor & Wagner, 1987). Cumene was negative in an Ames assay at concentrations up to 3606 μg/plate with S. typhimurium strains TA98, TA100, TA1535, and TA1537 (Florin et al., 1980). Cumene also tested negative, with and without metabolic activation, in a set of HGPRT assays (using Chinese hamster ovary cells) at cumene concentrations of 100-125 μg/ml, at which the relative cloning efficiencies (a measure of cytotoxicity) ranged from 29% to 110% (Gulf Life Sciences Center, 1985a; Yang, 1987). A micronucleus assay performed in mice given up to 1 g cumene/kg body weight by gavage was negative (Gulf Life Sciences Center, 1985b). Micronucleus assays done in Fischer-344 rats, however, gave values that were weakly positive, although little dose-response was seen, and deaths occurred at the highest dose (5 of 10 animals at 2.5 g/kg body weight intraperitoneally; NTP, 1996). The positive control used in the micronucleus tests, cyclophosphamide, produced strong positive responses in all assays.     Cumene failed to induce significant rates of transformation in BALB/3T3 cells (without activation) at concentrations up to 500 μg/ml (Putnam, 1987) but tested positive in an earlier cell transformation test also using BALB/3T3 cells, in which an increase in transformations was observed at 60 μg/ml (Gulf Oil Corp., 1984a). Results from an unscheduled DNA synthesis assay in rat hepatocytes conducted by Gulf Oil Corp. (1984b) indicated positive results at doses of 16 and 32 μg cumene/ml (with 128 μg/ml noted as toxic to the hepatocytes). However, apparent technical difficulties with this test (US EPA, 1988) prompted a repeat of the unscheduled DNA synthesis assay in rat hepatocytes, the results of which showed cumene to be clearly negative at doses up to 24 μg/ml, with doses above 24 μg/ml noted as being too toxic for evaluation of unscheduled DNA synthesis (Curren, 1987; US EPA, 1988). References ・Curren RD (1987) Unscheduled DNA synthesis in rat primaryhepatocytes -- test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.380005; TSCA section 4 submission 40-8792124). ・Florin I, Rutberg L, Curvall M, Enzell CR (1980) Screening of tobacco smoke constituents for mutagenicity using the Ames test. Toxicology, 18:219-232. ・Gulf Life Sciences Center (1985a) CHO/HGPRT test of cumene. Pittsburgh, PA. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2128; TSCA section 8(d) submission 878216011). ・Gulf Life Sciences Center (1985b) Micronucleus test of cumene. Pittsburgh, PA. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2129; TSCA section 8(d) submission 878216015). ・Gulf Oil Corp. (1984a) Cell transformation test of cumene. Houston, TX. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2131; TSCA section 8(e) submission 888500694). ・Gulf Oil Corp. (1984b) Hepatocyte primary culture/DNA repair test ofcumene. Houston, TX. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Gulf Project No. 84-2130; TSCA section 4 submission 888500694). ・Lawlor TE, Wagner VO (1987) Salmonella /mammalian-microsomepreincubation in mutagenicity assay (Ames test); test article:Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.502009; TSCA section 4 submission 40-8792121). ・NTP (1996) In-vivo cytogenetics testing results for cumene,micronucleus induction results. Available from National Toxicology Program, National Institute for Environmental and Health Sciences, Research Triangle Park, NC. ・Putnam DL (1987) Chromosome aberrations in Chinese hamster ovary(CHO) cells -- test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.337012; TSCA section 4 submission 40-8792123). ・US EPA (1988) Cumene; final test rule. Federal register, 53(144) :28195-28206. ・US EPA (1997) Integrated Risk Information System (IRIS) online at http://www.epa.gov/iris (including the Toxicological review ofcumene in support of summary IRIS information, National Center for Environmental Assessment, Cincinnati, OH). Washington, DC, US Environmental Protection Agency. ・Yang LL (1987) CHO/HGPRT mutation assay; test article: Cumene. Bethesda, MD, Microbiological Associates, Inc. Washington, DC, US Environmental Protection Agency, Office of Toxic Substances (Study No. T4786.332010; TSCA section 4 submission 40-8792124).

● Curcumine 　(クルクミン）
　　　 458-37-7 　Natural 　 283.24

AM	Sal	Max (?)	□	1)
CA	CHL/IU	Min ( 0.02 mｇ/ml, -S9), 24-48h; D20= 0.023; TR= 400	○	2)

1) Natl Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998）  (Tables in English)

● Curdlan 　（カードラン）
　　　　54724-00-4 　　Food

REC	B. subtilis	Max ( 2.0 mｇ/disk)	□	1)
AM	Sal.	Max ( 3.0 mｇ/plate)	□	1)
CA	CHL/IU	Max ( 5.0 mｇ/ml, ±S9)	□	2)
MN	CHL/IU	Max ( 5.0 mｇ/ml, ±S9)	□	3)

1) (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998）  (Tables in English)
3) (?)

● Cyanazine 　(Bladex) （グラメックス）　
　　　 21725-46-2　 　Pesticide　 240.70

REC	B. subtilis	Max ( 2.0 mｇ/disk)	□	1)
AM	Sal.	Max ( 3.0 mｇ/plate)	□	1)
HMA	(?)	Max (?)	□	1)
DLv	Mice	Max (?)	□	1)

1) Shell Chem. Co. Ltd., J. Pesticide Sci., 11, 127-130 (1986)

● Cyanoguanidine (Dicyanodiamide)（サイアノグアニジン）
　　 461-58-5 　Industry 　 84.08

AM	Sal./E.coli	Max ( 5.0 mg/plate)	□	1 ,2)
CA	CHL/IU	Max ( 0.84 mｇ/ml, ±S9), 6-18h	□	1)

1) Ministry of Health, Japan (Ed.): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998)  (Tables in English)
2)  Minstry of Labour, Japan; Mutagen. Test Data of Exist. Chem. Subst., JETOC (Ed.)(1996)  (Tables in English)

● Cyanopyridine （サイアノピリジン）
　　100-54-9 　Industry 　 104.12

AM	Sal./E.coli	Max ( 5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max ( 5.0 mｇ/ml, ±S9), 6-18h	□	1)

1) Ministry of Health, Japan (Ed.): Toxicity Testing Reports of Environ. Chemicals, Vol.5(1997)  (Tables in English)

● 2,2'-o-Cyclocytidine -HCl 　（２，２’−０−サイクロシチジン･塩酸）
　　　 10212-25-6　 Medicine 　 261.69

CA

CHL/IU

Min (0.002 mｇ/ml, -S9), 48h; D20= 0.0025 mg/ml; TR= 7000

◎

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998）  (Tables in English)

● β-Cyclodextrin （β-サイクロデキストリン）
　　  7585-39-9　Food/Natural 　　 1134.99

AM	Sal.	Max ( 10 mg/plate, ±S9)	□	1)
CA	CHL/IU	Max (4.0 mｇ/ml, -S9), 24-48h: (No data for +S9)	□	2)

1) Ishidate, MJr. (Ed.) Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998）  (Tables in English)

● Cyclohexane　（サイクロヘキサン）
　　　 110-82-7　Industry　　 84.16

AM	Sal.	Max ( 1.0 mｇ/plate, ±S9)	□	1, 2)
CA	CHL/IU	Max ( 0.75 mｇ/ml, -S9), 24-48h: Max ( 4.0 mg/ml, ±S9), 6-18h	□	3)

1) McCann J, et al,: Proc. Natl. Acad. Sci. (USA), 72, 5135-5139 (1975)
2) Ishidate, MJr. (Ed.) Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC (1991)  (Tables in English)
3) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998）  (Tables in English)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）

●Mutagenicity 　（変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト)

●Evaluation of Results　（試験結果の評価）