Group D-10

化学構造　(Chemical Structure)

● 1,1-Dimethylhydrazine (UDMH） （1,1-ジメチルヒドラジン)　
　　  CAS： 57-14-7　Jet fuels　　MW. 60.12

AM	Sal.	Min (?)	○	1-4)
AM	Sal/E. coli	Min ( 1.25 mg/plate, -S9)	○	16)
HMA	E. coli	Min (?)	○	5)
MB	λ-Prophage/ E. coli	Max(?)	□	6)
MLA	L5178Y	Min (?)	○	2, 7)
SM	CHO	Min (?)	○	8)
UDS	Rat/Hepatocytes	Min (?)	○	5)
SCE	CHO	Min (?)	○	9)
CA	CHO	Min （0.025 mg/ml, -Ｓ9), 24h	○	9)
CA	CHL/IU	Min （0.025mg/ml, -S9）, 24-48h; D20= 0.013; TR= 640	◎	10)
CA	CHL/IU	Min （0.04 mg/ml, -S9）, 24h; D20= 0.03; TR= 680	○	17)
MNv	Dogs	Max(?)	□	11)
DLv	Mice	Max(?)	□	2, 12)
SPMv	Mice	Min (?)	○	13)
MNv	Mice/Liver	Max(?), (96h)	□	14)
DNA	Rat/Lung, Liver	Min (?)	○	15)

1) Rogan EG., et al.: Mutation Res., 102, 413-424(1982)
2) Matheson D., et al: Mutation Res., 53, 93-96 (1978)
3) Tosk J., et al.: Mutation Res., 66, 247-252 (1979)
4) Parodi D., et al.: Cancer Res.,41, 1469-1482 (1981)
5) Lingens F.: Z. Naturforsch., 19B, 151-156 (1964)
6) Heinemann B.: Appl. Microbiol., 21, 726-731 (1971)
7) Rogers AM., et al.: Mutation Res., 89, 321-328 (1981)
8) Kuszynski C., et al.: Environ. Mutagen., 3, 323-324 (1981)
9) Calandra TD., et al.: Environ. Mol. Mutagen., suppl. 15, 12 (1990)
10) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test: In vitro, LIC, Tokyo/Elsvier, Amsterdam (1988)
11) Beng RO & Beltz PA.: Environ. Mutagen. 2, 312-313 (1980)
12) Epstein SS., et al.: Toxicol. Appl. Pharmacoll, 23, 288-325 (1972)
13) Wyrobeck AJ. & Bruce WR.: Proc. Natl Acad. Sci., 72, 4425-4429 (1975)
14) Cliet I.., et al.: Mutation res., 216, 321-326 (1989)
15) Parodi S., et al.: Proc. Am. Assoc. Cancer Res., 21, 99 (1980)
16) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), pp.197 (1996)  (Tables in English)
17) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.),Suppl., pp.282 (1997)  (Tables in English)

IARC Carcinogenicity Criteria：
Group 2B 　(Possibly carcinogenic in humans)

● 1,2-Dimethylhydrazine 2-HCl
　　　 306-37-6 　Industry　　 133.02

CA

CHL/IU

Max ( 1.0 mg/ml)

□

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)

● Dimethylmalonate (マロン酸ジメチル）　
　   108-59-8 Industry　 132.12

AM

Sal./E.coli

Max ( 5.0 mg/plate, ±S9)

□

1)

1) Ministry of Labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., Suppl. 2, JETOC(Ed.), (2000), pp. 203  (Tables in English)

● Dimethyl 2,6-naphthalenedicarboxylate （2,6-ナフタレンジカルボキシ−メチルエステル）
　　　 840-65-3　Industry 　 244.25

AM	Sal.	Max （5.0 mg/plate,±S9)	□	1)
CA	CHL/IU	Max ( 1.2 mg/ml; ±S9), 6-18h	□	1)

１） Ministry of Health, labour & Welfare, Japan (Ed): Tox Test. Re.p of Environ. Chemicals, Vol. 5 (1997)  (Tables in English)

● Dimethylnitrosamine (DEN) （ジメチルニトロサミン）(See also N-5)
　　 　 62-75-9　labouratory　 74.08

REC	Sal./E. coli	Min (5 x 10-2 μg/well	○	1)
AM	Sal.	Min ( 50 mg/ml, +S9)	○	2)
CA	Human LY	Min ( 50 μM, +S9)	○	3)
CA	CHO	Min ( 27mM, +S9)	○	4)
CA	CHL/IU	Min ( 0.5 mg/ml, +S9), 6-18h; D20= 0.53, TR= 63	○	5)
SCE	Human LY	Max ( 500 μM, -S9)	□	6)
SCE	CHO	Min ( 2.7mM, +S9)	○	4)
SM	V79/8AG	Min (10 mM, +S9)	○	7)
UDS	HeLa cells	Min (10 -4M +S9)	○	8)
CT	BHK21c113	(Soft agar method), Min (?)	○	9)
CAv	Rat/LY	Min ( 30 mg/kg), ip	○	10)

１） Ichinotsubo D. et al, : Mutation Res., 46, 53-62 (1977)
2) Gletten F. et al.: Mutation Res., 28 113-122 (1975)
3) Binboes D & Greim H: Mutation Res., 35, 155-160 (1976)
4) Natarajan AT, et al,: Mutation Res., 37. 83-90 (1976)
5) Ｉｓｈｉｄａｔｅ　ＭＪｒ．（Ｅｄ．）: Ｄａｔａ　Ｂｏｏｋ，Ｃｈｒｏｍｏｓｏｍａｌ　Ａｂｅｒｒａｔｉｏｎ Ｔｅｓｔ in vitro, LIC/Tokyo & Elsevier/Amsterdam (1988)
6) Craig-Holmes AP & Shaw MW: Mutation Res., 46, 375-384 (1977)
7) Kuroki T, et al,: Cncer Res., 37, 1044-1050 (1977)
8) Martin CN. et al,: Cancer Res., 38, 2621-2627 (1978)
9) Styles JA.: Br. J. Cancer, 37, 931-936 (1978)
10) Lilly LJ, et al.: Nature, 258, 611-612 (1975)

● 1,4-Dimethyl-2-(1-phenylethyl) benzene （1,4-ジメチル-2-(1-フェニル−エチル)ベンゼン）
　　　　 6165-51-1　Industry 　 210.31

AM	Sal.	Max （5.0 mg/plate,±S9)	□	1)
CA	CHL/IU	Max ( 2.1mg/ml; +S9), 6-18h	□	1)

１）Ministry of Health, labour & Welfare, Japan (Ed): Tox.Test.Rep. Environ. Chem., Vol. 9 (2002)(Tables in English)

● N,N'-Dimethyl-p-phenylenediamine
　　　 99-98-9　Medicine　　　 136.20

AM	Sal.	Min (?)	○	1)
CA	CHL/IU	Min ( 0.01 mg/ml, -S9), 24h　D20= 0.01; TR= 900	○	2)

1) Zeiger E. et al.: Environ. Mol. Mutagen., 19 (Suppl, 21)2-141 (1992)　
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)

● 3,4-Dimethylphenyl-N-methylcarbamate (MPMC)
　　　 2425-10-7　Pesticide　　 179.22

CA

CHL/IU

Min ( 0.125 mg/ml, -S9), 48h　D20= 0.34 (No exchanges)

○

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998)  (Tables in English)

● 3,4-Dimethylphenyl-N-nitroso-N-methylcarbamate
　　　 58139-33-6　labouratory　 208.22

CA

CHL/IU

Min ( 0.015 mg/ml, -S9), 24h　D20= 0.009; TR= 5100

◎

1)

1) Ishidate MJr (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC/Tokyo, Elsevier/ Amsterdam (1988)

● O,O-Dimethyl phosphorochlorideothioate
    2524-03-0　　Industry 　 160-56

AM	Sal.	Min （0.0781 mg/plate,+S9), spa=1.05 x 103(E. coli)	□	1)
CA	CHL/IU	Min ( 0.03 mg/ml; -S9), 6-18h; Poly also	□	1)

1) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), Suppl. 2, pp. 50 (2000)  (Tables in English)
1) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), Suppl. 3, pp. 232 (2005) (Tables in English)

● Dimethylphthalate (DEP)（ジメチルフタレート）
　　　131-11-3　　Industry 　 194.19

US-NTP Genotoxicity Screening：
○ Ames Test：　□
○ MLA：　□
○ CA Test with CHO Cells：　□
○ SCE Test with CHO Cells：　□

● 2,2-Dimethyl-1,3-propanediol　（2,2-ジメチル-1，3-プロパンジオール）
　　　　 126-30-7　Industry 　 104.15

AM	Sal./E. coli	Max （ 5.0 mg/plate,±S9)	○	1, 2)
CA	CHL/IU	Max ( 1.0 mg/ml; ±S9), 6-18h	○	2)

1) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), Suppl. 2, pp. 54 (2000)  (Tables in English)
2）Ministry of Health, labour & Welfare, Japan (Ed): Tox.Test. Rep. Environ. Chemicals, Vol. 1 (1994) (Tables in English)

● Dimethyl sulfate　（硫酸ジメチル）
　　 77-78-1　Industry　　 126.1

AM	Sal.	Min ( 0.04 mg/ml, -S9)	○	4)
CA	Vicia fava (ソラマメ)	Min ( 10-4M)	○	1)
CA	CHL/IU	Min ( 0.04 mg/ml, -S9); D20= 0.027; TR= 860	○	2)
SCE	Hum. Fb	Min ( 1.5 μｇ/ml, -S9)	○	5)
SM	CHO	Min (2.5 μｇ/ml, -S9)	○	6, 7)
SM	CHO/8TG	Min ( 10 μM)	○	3)
SM	V79	Min ( 8μg/ml, -S9)	○	7)
UDS	Rat hepatocytes	Min ( 12.6 μg/ml, -S9)	○	3)
CAv	Rats, BM	Min ( 0.35 mg/kg)	○	7)
CAv	Mice, BM	Min ( 3.85 ppm, ih)	○	7)
DLv	Mice	Max (?)	□	5, 7)
SLRLv	Drosophila	Min (?)	○	5)
DNAv	Mice, testis	Min (?)	○	5)

１） Strelid S. & Kihlman A.: Hereditas, 88, 27-33 (1978)
2) Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), pp. 480 (1996)  (Tables in English)
3) Cough DB., et al.: Mutation Res., 57, 217-224(1978)
4) Skopek TR. et al., Proc. Natl., Acad. Sci, USA, 75, 4465-4469 (1978)
5) Hoffmann GR, Mutation Res., 75, 63-129 (1980)
6) Tan EL, J. Toxicol. and Environ. Health,  11, 373-380 (1983)
7) IPCS/WHO, Environ. Health Criteria, 48 (1985)

　IARC Carcinogenicity Criteria：
　Group 2A (Probably carcinogenic in humans)

【Note】 (Cited from IARC Monograph, Suppl., 6 (1987)

It is an alkylating agent. No data were available on the genetic and related effects of this compound in humans. 　　It induced both structural and numerical CAs in bone-marrow cells of rats treated in vivo and chromatid breaks in mouse embryos treated transplacentally. It alkylated DNA in rats treated in vivo and in cultured rodent cells. It induced SCEs, UDS and DNA strand breaks in human and rodent cells in vitro, and CAs and mutation in cultured rodent cells. It induced SLRL mutations in Drosophila and mutation and mitotic recombination in yeast. Conflicting results were obtained for CAs and mutation in plants. It induced mutation and DNA damage in bacteria.

● Dimethyl terephthalate （ジメチルテレフタレート） (p-フタル酸ジメチル;　（1,4-ベンゼン-
　　　ジカルボキシ酸ジメチルエステル）
　　　　 120-61-6　Labolatory　　 194.19

AM	Sal./E.coli	Max ( 5.0 mg/platae, ±S9)	□	1)
AM	Sal.	Max ( 3.3 mg/platae, ±S9)	□	2-4)
MLA	Y5178Y	Max ( 0.1 mg/ml, ±S9)	□	5)
CA	CHL/IU	Max ( 2.0/ml; -S9), 24-48h　(No data for +S9)	□	6, 7)
CA	CHO	Max ( 10 mg/ml, ±S9)	□	8)
MN	Human lym.	Max ( 0.5mg/ml; -S9), for 72h　(No data for +S9)	□	3, 4)
SCE	CHO	Max ( 10 mg/ml, ±S9)	□	8)
UDS	HeLa cells	Max ( 5 mg/ml, ±S9)	□	3, 4)
CT	Ham. SA/SHE	Max ( 1 mg/ml, -S9, (No data for +S9)	□	8)

１）Ministry of labour, Japan: Mutagen. Test. Data of Exist. Chem. Subst., JETOC(Ed.), pp. 174 (1996)  (Tables in English)
2) Zeiger E., et al., Environ Health Perspect., 45, 99-101 (1982)
3) Lerda DE, Int. J. Environ Health Res., 6, 125-130 (1996)
4) Monarca S., et al., Mutation Res., 262, 85-92 (1991)
5) Myhr BC & Caspury WJ., Environ. Mol Mutagen., 18, 51-83 (1991)
6) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In VitroLIC, Tokyo (1998) (Tables in English)
7) Ishidate MJr. et al., Mutation Res., 195, 151-213 (1988)
8) Loveday KS., et al., Environ. Mol Mutagen., 16, 272-303 (1990)
9) Heidelbergaer C et al., Mutation Res., 114, 283-285 (1983)

● N,N''-Dimethyltriptamine　（N,N'-ジメチルトリプタミン）　　
　　　　 61-50-7　Industry /Solvent　　 188.27

AM	Sal.	Max (?)	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml; -S9), 24-48h　(No data for +S9)	□	2)

１） (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)

●Top Page　（トップページ）

●Abbreviation 　（省略記号）

●Mutagenicity 　（変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）