Group D-13 ‰»Šw\‘’@(Chemical Structure)  

œ Di-sec-octyl phathalate iƒW-sec-ƒIƒNƒ`ƒ‹ƒtƒ^ƒŒ[ƒgG DEHPGDOPj@
@@@CASF 117-81-7@@Plasticizer@@MW; 390.54
AM Sal. Max (?)
 
1)
CA CHL/IU Max (0.16 mg/ml, }S9)
 
2)
SCE Don Max (?)
 
3)
MNv Mice/BM Max (?)
 
1)
UDS Rat/Hepatocytes Max (?)
 
1)
CT  (?) Min (?)
›
1)
‚Pj Garberg P., et al.: NIOH, NIODH, Arbete Och Halsa, 25, 1-53 (1989)
2)  Ishidate MJr. & Odashima S.: Mtutation Res., 48. 337-354 (1977)
3) Abe S. & Sasaki M.: J. Natl Cancer Inst., 58, 1635-1641 (1977)

 US-NTP Genotoxicity ScreeningF
›@Ames TestF@
  
›@SCE Test with CHO Cells:F@’
›@CA Test with CHO CellsF@ 
›@MN Test in Mice (Bone Marrow)F@ 
›@SLRL Test with Drosophila:F@ 

ARC Carcinogenicity CriteriaF @
 Group 2B @
iPossibly carcinogenic in humansjiAn environmental hormon?j

œ Disodium dihydrogen pyrophosphate
@@@
7758-16-9@Food@@ 221.94
AM Sal. Max ( 10.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 0.5 mg/ml, -S9), 24-48h;@(No data for +S9)
 
2)
1) Ishidate MJr.(Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991)  (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998)  (Tables in English)

œ
Disodium 4,4'-dinitrostilbene-2,2'-disulfonate +
@@@ 3709-43-1@Industry@@ 474.32
AM Sal./E. coli Max ( 10 mg/plate)
 
1)
1)Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.) Suppl. 2, pp. 172 (2000) (Tables in English)

œ Disodium glycyrrhizinate iƒOƒŠƒ`ƒ‹ƒŠƒ`ƒ“Ž_“ρƒiƒgƒŠƒEƒ€j@
@@@71277-79-7 @@ Food @@866.92
AM Sal. Max ( 5.0 mg/plate, }S9)
 
1)
CA CHL/IU Min ( 2.0 mg/ml, -S9), 24-48h; D20= 2.4; TR= 8.0
›
2)
CA Mice/BM Max ( 20 mg/ml x 4), ip, 24h
 
3)
1) Ishidate MJr.(Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)
3) Hayashi M, et al,: Fd. Chem. Toxicol., 6, 487-500 (1988)

œ Disodium succinate
@@@150-90-3@Food/Medicine@@ 275.15
AM Sal. Max ( 5.0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 15.0 mg/ml, -S9), 24-48h
 
2)
1) Ishidate MJr.(Ed.): Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)

œ Disodium succinate hexahydrate iƒRƒnƒNŽ_“ρƒiƒgƒŠƒEƒ€˜Z…˜a•¨j
@@@6106-21-4@Food@@ 270.14
AM Sal. Max ( 5,0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 5.0 mg/ml, }S9), 6-18h
 
1)
1) Ministry of Health, Labor & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 9 (2002)

œ Disperse Yellow 42 iƒWƒXƒp[ƒX‰©F42j@
@@@5124-25-4@Food@@ 369.40
AM Sal. Max ( 5,0 mg/plate, }S9)
 
1)
CA CHL/IU Min ( 0.08 mg/ml, }S9), 6-18h
›
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 9 (2002) (Tables in English)

œ Disulfiram @(ƒWƒXƒ‹ƒtƒ‰ƒ€G@Antabusej @
@ @@ 97-77-8@@Medicine@@ 296.54
CA Human LY Min (?)
›
1)
‚Pj Lilly LJ,: Toxicol., 4, 331-340 (1975)
@@
@
US-NTP Genotoxicity ScreeningF
@›
Ames TestF@ 
@
›@MLA (L-5178Y)G@›
@
› CA Test with CHO CellsF@ 
@
› SCE Test with CHO CellsF@›
@@
@IARC Criteria for CarcinogenicityF@
@Group 3@
iNot classifiable as to its carcinogenicity to human)

œ 4,4'-Dithiodimorpholine (NCN'-Dithiobis (morpholine))
@@
103-34-4 @Industry @ 236.35
AM Sal./E. coli Max ( 10 mg/plate, }S9)
 
1)
1)Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.), pp. 132 (1996) (Tables in English)

œ Dithiopyr
@@
97886-45-8 @Psticide @ 401.4
REC B. subtilis Max ( 20.0 m‚‡/disk )
 
1)
AM Sal. Max ( 5.0 m‚‡/plate, }S9)
 
1)
CA CHL/IU Max ( 1.0 mM/}S9)
 
1)
SM (HGPRT) Max (?)
 
1)
UDS Hepatocytes Max (?)
 
2)
1) Monsanto Co. Ltd.: J. Pesticide Sci., 18, S91-S97 (1993) (In Japanese)
2)
SRI Internat. (1987) (?)

œ Ditridecyl phthalate iƒWƒgƒŠƒfƒVƒ‹ƒtƒ^ƒŒ[ƒgj
@@@119-06-2@Industry @ 530.83
AM Sal./E. coli Max ( 5,0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 4.75 mg/ml, }S9), 6-18h
 
1)
1) Ministry of Health, & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998) (Tables in English)

œ Divinyl benzene iƒWƒrƒj[ƒ‹ƒxƒ“ƒ[ƒ“j
@@
1321-74-0 @industry/Monomer @ 130.19
AM Sal./E. coli Max ( 0.078 mg/plate}S9)
 
1)
YM Yeast (Mitotic gene conversion) Max (?)
 
1)
1) 1)Ministry of Labour, Japan: Mutagenicity Test Data of Exist. Chem. Subst., JETOC (Ed.),Suppl. 3, pp. 197 (1996) (Tables in English)
2j Simmon VF.: (Unpublished Report); LSC-4378, Stanford Res. Insti., Menlo Park, CA (1976)

 US-NTP Genotoxicity ScreeningF
@› Ames TestF
 

œ Docosanoic acid iƒhƒRƒTƒ“Ž_j
@@
112-85-6@Industry@ 340.59
AM Sal./E. coli Max ( 5,0 mg/plate, }S9)
 
1)
CA CHL/IU Max ( 3.5 mg/ml, }S9), 6-18h
 
1)
1) Ministry of Health, Labour & Welfare, Japan (Ed): Toxicity Testing Reports of Environ. Chemicals, Vol. 6 (1998) (Tables in English)

œ Dry canthaxanthin
@@@514-78-3@Food dye@ MW: 564.82
CA CHL/IU Max ( 1.0 mg/ml, -S9), 24. 48h
 
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test iIn vitro, LIC, Tokyo (1998)

œ Dunaliella carotene

@@@ Food @@@@@( Purity: 32.06% ƒΐ-carotene)
CA CHL/IU Max ( 0.5 mg/ml, }S9), 6-18h
 
1)
1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In vitro, LIC, Tokyo (1998) (Tables in English)
œTop Page@iƒgƒbƒvƒy[ƒWj
œAbbreviation @iΘ—ͺ‹L†j@
œMutagenicity (•ΟˆΩŒ΄«j
œTest Systems@(ŽŽŒ±–@‚ΜŽν—ށj
œTechnical Problems@i‹Zp“I–β‘θ“_j
œList of@Compoundsi‰»‡•¨ƒŠƒXƒgj
œEvaluation of Results@iŽŽŒ±Œ‹‰Κ‚Μ•]‰Ώj