|@@In single studies, lymphocytes of persons occupationally exposed to
this chlorophenoxy herbicides, including 2,4-D, did not show increased
frequencies of SCEs or CAs. Other studies could not be assessed since workers
were also exposed to other formulations.
@@2,4-D did not induce DL mutations, MNs or SCEs in rodents treated in vivo. Pure 2,4-D did not induce CAs in human lymphocytes in vitro, whereas a commercial formulation did (Mustonen, Kagas, Vuojalahti, 241, 1986); it induced SCEs and UDS in human cells in vitro. It did not induce SCEs but did induce mutation and inhibited intercellular
communication in Chinese hamster cells in vitro. It induced somatic mutation in Drosophila, but conflicting results were obtained for induction of SLRL mutations; it did not induce aeuploidy. It cause CAs and was mutagenic in plants. It induced mutation, gene conversion and mitotic recombination in yeast. It was not mutagenic to bacteria or bacteriophage. The n-butyl and iso-octyl esters of 2,4-D were also not mutagenic to bacteria (Mortelmans, haworth, Speck, 157, 1984)
(IARC Monographs, 15, 111)