Group F-3

化学構造　(Chemical Structure)

● Flavophospholipol 　(Flavomycin; Banbermycins)
　　 CAS：11015-37-5　　Agriculture MW:

CA

CHL/IU

Max ( 2.0 mg/ml)  (No data for +S9)

□

1)

1) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo (1998) (Tables in English)

● Floxuridine
　　 50-91-9 　Medicine 　246.21

HMA	Sal/G46	Max ( 2 mg/kg, , mice)	□	1)
MB	Phage/PBS2	Min ( 5 μg/ml)	○	2)
CA	Human LY	Min ( 0.5 mg/ml)	○	3)
SM	CHO/6TG	Min ( 0.2μg/ml)	○	4)
CT	C3H 10T1/2	Min ( 10-7 M)	○	5)

1) Gabidge MG & Legator MS: Proc. Soc. Exp., Med., 130, 831- (1969)
2) Smith RH* Mutation Res., 20, 276 (1973)
3) Stopik D: Humangenetik, 14, 24-32 (1971)
4) Aebersold PM: Cancer Res., 39, 808-810 (1979)
5) Jones PA, et al,: Cancer Res., 36, 101-107 (1976)

● Fluazifop-butyl 　(Onecide)
　　　69806-50-4 　Pesticide 　 383

REC	B. subtilis	Max (?)	□	1)
AM	Sal	Max (?)	□	1)
CA	?	Min (?)	○	1)
DLv	Mice	Max (?)	□	1)

1) Ishihara Sangyo Co. Ltd.: J. Pesticide Sci., 15, 305-310 (1990) (in Japanese)

●Fluometuron
　　　2164-17-2 　Pesticide　 232.21

AM	Sal/G46	Min ( 100 μg/plate, -S9)	○	1)
AM	Sal/TA1535	Max ( 100 μg/plate, +S9)	□	2)
YM	S.serevisiae	Max ( 0.125 mg/ml, -S9), 24, 48h　(No data for +S9)	□	3)

1) Seiler JP: Mutation Res., 48, 225-236 (1977)
2) Seiler JP: Mutation Res., 58, 353 (1978)
3) Siebert D & Lemperle E: Mutation Res., 22, 111-120 (1974)

● Fluoranthene 　(Benzo[jk]fluorene)
　　 206-44-0 　Laboratory 　　 202.26　

CT

Rat/embryo

Min ( 50 μg/ml, -S9)

○

1)

1) Freeman AE, et al,: J. Natl. Cancer Inst., 51, 799 (1973)

● Fluorene
　　　86-73-7 　　Laboratory　 　 166.21

AM	Sal	Max ( 1 mg/plate, ±S9)	□	1)
MLA	L5178Y	Max ( 30 μg/plate, ±S9)	□	2)

1) McCann J, et al,: Proc. Natl. Acad. Sci.(USA), 72, 5135-5139 (1975)
2) Oberly TJ., et al., Mutation Res., 125, 291-306 (1984)

● Fluorescent brightner 24 　(Kayaphor SN)
　　12224-02-1　 Industry/dye 　 1169.06

AM	Sal	Max ( ?)	□	1)
CA	CHL/IU	Max ( 2.0 mg/ml, -S9), 24, 48h　(No data for +S9)	□	2)

1) Natl. Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test in vitro LIC, Tokyo (1998) (Tables in English)

● Fluorescent brightner 225　(Kayaphor LSK)
　　　　　　　　 Industry/dye 　 952.97

AM	Sal	Max ( ?)	□	1)
CA	CHL/IU	Max ( 0.125 mg/ml, -S9), 24, 48h　(No data for +S9)	□	2)

1) Natl. Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Fluorescent brightner 260 　(Whitex SA)
　　　16090-02-1　　　　　 Industry/dye 　 924.92

AM	Sal	Max ( ?)	□	1)
CA	CHL/IU	Max ( 0.03 mg/ml, -S9), 24, 48h　(No data for +S9)	□	2)

1) Natl. Inst. Hygien. Sci., Tokyo (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● 5-Fluorouracil 　(5-FU)
　　　51-21-8　Medicine 　 130.08

AM	Sal	Min (?)	○	1)
MB	C. reinhardi (クラミドノマス）	Min (?)	○	2)
CA	CHL/IU	Min ( 0.003 mg/ml, -S9), 24, 48h (No data for +S9)	○	3)
CT	C3H 10T1/2	Min ( 10-5 M -S9)	○	4)
MNv	Mice/ICR	Min ( 15 mg/kg, ip)	○	5)

1) Zeiger E, et al,: Environ. Mol. Mutagen., 19, (suppl 21), 2-141 (1992)
2) Lawrence CW & Davies DR: Mutation Res., 4, 137 (1967)
3) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test In Vitro, LIS/Japan, Elsvier/Amsterdam (1988)
4) Jones PA, et al,: Cancer Res., 36, 101-107 (1976)
5) Matter P & Schmid W: Mutation Res., 40, 325-338 (1976)

【Note】 (Cited from IARC Monographs, Suppl.., 6 (1987)

Neither CAs (in two patients) nor SCEs (in three patients) were induced following administration of 5-FU. 　　5-FU induced MNs but not specific locus mutations in mice treated in vivo. It induced aneuploidy, Cas and SCEs in cultured Chinese hamster cells. It did not induce SLRL mutations in Drosophila, but caused genetic crossing-over in fungi. Studies on mutation in bacteria wee inconclusive　(IARC Monographs, 26, 217)