Group H-1

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

Group H-1 化学構造　(Chemical Structure)

● Haloperidol （ハロペリオドール）
　　 CAS：52-86-8　Medicine 　MW: 375.87

AM Sal. Max (?), ±S9 □ 1)

CA CHL/IU Max ( 0.015 mg/ml, -S9), 24, 48h (No data for +S9) □ 2)

CAv Hum. Ly (?) ? 3)

SCEv Hum. Ly (?) ? 4)

PLNv Allium cepa (?) ? 5)

(?) (?) (?) ? 6)

1) (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
3)Smith M., et al., Am. J. Medi Genet., 67 (2) 238 1996)
4) Tucker JD., et al., Mutation Res., 297, 101--80 (1993)
5) Grant WF, Mutation Res., 99, 273-291 (1982)
6) Van Cauteren H., et al., Drug Chem. Toxicol., 10, 311-327 (1987) ( under construction)

● Halothane 　(Bromochlorotrifluoroethane; Fluothane)　（ハロテン）
　　 151-67-7　Medicine　 197.39

AM Sal Max ( 30,000 ppm) □ 1)

CAv Rats Min ( 1 ppm mixed with 50 ppm of nitrous oxide) for 40 weeks ○ 2)

1) Baden JM, et al,: Anesthesiology, 45, 311-318 (1976)
2) Goate WB, et al,: Anesthesiology, 50, 310-318 (1979)

US-NTP Genotoxicity Screening:
○ Ames Test: □
○ RT Test with Drosophila: □
○ SLRL Test with Drosophila: ○
○ CA Test with CHO: □
○ SCE Test with CHO: □
○ Ames Test: □

IARC Carcinogenicity Criteria:
　Group 3 (Not classifiable as to its carcinogenicity in humans)

【Note】 (Cited from IARC Monographs, Suppl.., 6 (1987)

　　No adequate data were available on the genetic and related effects of halothane in humans.
　　Halothane did not induce DL mutations, CAs, MNs or SCEs in rodents treated in vivo. It did not cause SCEs in cultured CHO cells. It caused mutation and gene conversion in yeast under conditions that enhanced endogenous levels of cytochrome P450. It did not induce mutation in bacteria. (IARC Monographs, 11, 285)

● Heptachlor 　(3-Chlorochlordene) （ヘプタクロール）
　　 76-44-8 　Insectcide 　 373.32

AM Sal Max ( 5.0 mg/plate) □ 1-3)

AM E. coli Max (?) □ 4)

REC B. subtilis Max (?) □ 4)

CA CHL/IU Min ( 0.125 mg/ml, +S9), 6-18h ○ 5)

MLA L5178Y Min (?) ○w 6)

UDS Rat/Mouse/Hamster
Hepatocytes Max (?) □ 7, 8)

UDS Human/VA-4 Min (?) ○ 9)

DNA E. coli Max (?) □ 10)

MCO Rat-liver cell line ( 6-TG sensitive) Min (?) ○ 11)

SLRL Drosophila Max ( 5 μg/ml) □ 12)

CA Mice/BM Min ( 5.2 mg/kg, ip) , 21h ○ 13)

DLv Mice Max ( 24 mg/kg x1, ip) or (10 mg/kg x 5, po) □ 14)

Other Mice/testicular DNA Max ( 40 mg/kg, po) □ 15)

1) Ishidate MJr (Ed): Data Book ofr Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Marshall TC, et al,: J. Agric. Food. Chem. 24, 560-563
3) Moriya M, et al,: Mutation Res, 116, 185-216
4) Shirasu Y, et al,: Mutation Res., 40, 19-30 (1976)
5) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
6) McGregor DB, et al,,: Environm. Molecul. Mutagen., 12, 85-154 (1988)
7) Probst GS, et al,: Environ. Mutagen., 3, 11-32 (1981)
8) Maslansky CJ & Williams GM: J. Toxicol. Environ. Health, 8, 121-130 (1981)
9) Ahmed FE, et al,: Mutation Res., 42, 161-174 (1977)
10) Griffin DE & Hill WE: Mutation Res., 52, 161-169 (1978)
11) Talang S, et al,: Carcinogenesis, 3, 1175-1178 (1982)
12) Benes V & Sram R: Ind. Med., 38, 50-52 (1969)
13) Markaryan DS: Gentica, 1, 132-137 (1966)
14) Epstein SS, et al,: Toxicol. Appl. Pharmacol., 23, 288-325 (1972)
15) Seller JP: Mutation Res., 46, 305-310 (1977)

US-NTP Genotoxicity Screening:
○ Ames Test: □
○ MLA: ○
○ CA Test with CHO: ○

IARC Carcinogenicity Criteria:
　Group 3 (Not classifiable as to its carcinogenicity in humans)

【Note】 (Cited from IARC Monographs, Suppl.., 6 (1987)

　　No adequate data were available on the genetic and related effects of heptachlor in humans.
　　Heptachlor did not induce DL mutation in mice. It induced UDS in human fibroblast cultures but did not induce repair synthesis in cultured rodent cells. It inhibited intercellular communication in rodent cell systems; it was not mutagenic to cultured rat liver cells. It did not induce SLRL mutaion in Drosophila or gene conversion in yeast. It was mutagenc to plants. It was not mutagenic to bacteria, but in one study, positive results were reported for technical-grade but not commercial -grade heptachlor. It did not produce breakage of plasmid DNA. (IARC Monographs, 5, 173; 20,129)

● Heptachlor epoxide 　(Epoxyheptachlor) （ヘプタクロール　オキシド)
　　　1024-57-3　Industry　 389.32

AM Sal Max ( 10 mg/plate, ±S9) □ 1-3)

CA CHL/IU Min ( 012 mg/ml, -S9), 48h (No data for +S9) ○ 4)

UDS Human/VA-4 Min (?)(+S9) ○ 5)

1) Ishidate MJr (Ed): Data Book for Mutagenicity Tests on Chemicals in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Marshall TC, et al,: J. Agric. Food. Chem. 24, 560-563 (1976)
3) Moriya M, et al,: Mutation Res, 116, 185-216 (1983)
4) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
5) Ahmed FE, et al,: Mutation Res., 42, 161-174 (1977)

● Hexachlorobenzene （ヘキサクロロベンゼン）
　　118-74-1　 Industry 　 284.8

AM Sal Max ( 5.0 mg/plate, ±S9) □ 1 )

CA CHL/IU Max ( 12 mg/ml, ±S9), 6-18h □ 2)

SM V79/8AG Min (?) ○ 3)

DLv Rats/ Wistar Max ( 20 mg/ml, po ) □ 4)

1) Haworth S, et al,: Environ. Mol. Mutagen., 5 (suppl. 1), 3-142 (1983)
3) Ishidate MJr: (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo, Elsevier/Amsterdam (1988)
3) Simon GS, et al,: Toxicol. appl., Pharmacol., 47, 415-419 (1979)
4) Khera KS: Food Cosmet. Toxicol., 12, 471-477 (1974)

IARC Carcinogenicity Criteria:
　Group 2B (Possibly carcinogenic to humans)

【Note】 (Cited from IARC Monographs, Suppl.., 6 (1987)

　　No data were available on the genetic and related effects of hexachlorobenzene in humans.
　　Hexachlorobenzene did not induce DL mutation in rats treated in vivo. It did not induce CAs in cultured Chinese hamster cells or mutation in bacteria. (IARC Monographs, 20, 155)

● Hexachloro-1,3-butadiene （ヘキサクロロ-1，3-ブタジェン）
　　　87-68-3　Industry　　 260.76

AM Sal Max ( 5.0 mg/plate, ±S9） □ 1)

CA CHL/IU Min ( 0.025 mg/ml, -S9）, 24h (also poly); D20= 0.05; TR= 270 ○ 2)

1) Ishidate MJr (Ed): Data Book for Mutagenicity in Bacteria, LIC/Tokyo (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

US-NTP Genotoxicity Screening:
○ Ames Test: □
○ SLRL Test with Drosophila:: □
○ CA Test with CHO: □
○ SCE Test with CHO:○

IARC Carcinogenicity Criteria:
　Group 3 (Not classifiable as to its carcinogenicity in humans)

● Hexachlorocyclopentadiene （ヘキサクロロサイクロペンタジェン）
　　　　77-47-4 　Industry/Intermediate　　 272.75　

AM Sal. Max ( 0.5 mg/ml, ±S9) □ 1, 2)

MLA L5178Y Max ( 0.00125 mg/ml, ±S9) □ 3)

DLv Mice Max ( ? ) □ 4)

1) EPA/OTS; Doc .# 878214192
2) Haworth S., et al., Env. Mutagen., 5 (Sppl. 1) 3-142 (1983)
3) EPA/OTS; Doc .# 88-7800/02
4) EPA/OTS; Doc .# 40-7849064

US-NTP Genotoxicity Screening:
○ Ames Test: □
○ SLRL Test with Drosophila:: □
○ CA Test with CHO: ○　
○ SCE Test with CHO: ○　　　

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity 　（変異原性）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal.	Max (?), ±S9	□	1)
CA	CHL/IU	Max ( 0.015 mg/ml, -S9), 24, 48h (No data for +S9)	□	2)
CAv	Hum. Ly	(?)	?	3)
SCEv	Hum. Ly	(?)	?	4)
PLNv	Allium cepa	(?)	?	5)
(?)	(?)	(?)	?	6)

AM	Sal	Max ( 30,000 ppm)	□	1)
CAv	Rats	Min ( 1 ppm mixed with 50 ppm of nitrous oxide) for 40 weeks	○	2)

AM	Sal	Max ( 5.0 mg/plate)	□	1-3)
AM	E. coli	Max (?)	□	4)
REC	B. subtilis	Max (?)	□	4)
CA	CHL/IU	Min ( 0.125 mg/ml, +S9), 6-18h	○	5)
MLA	L5178Y	Min (?)	○w	6)
UDS	Rat/Mouse/Hamster Hepatocytes	Max (?)	□	7, 8)
UDS	Human/VA-4	Min (?)	○	9)
DNA	E. coli	Max (?)	□	10)
MCO	Rat-liver cell line	( 6-TG sensitive) Min (?)	○	11)
SLRL	Drosophila	Max ( 5 μg/ml)	□	12)
CA	Mice/BM	Min ( 5.2 mg/kg, ip) , 21h	○	13)
DLv	Mice	Max ( 24 mg/kg x1, ip) or (10 mg/kg x 5, po)	□	14)
Other	Mice/testicular DNA	Max ( 40 mg/kg, po)	□	15)

AM	Sal	Max ( 10 mg/plate, ±S9)	□	1-3)
CA	CHL/IU	Min ( 012 mg/ml, -S9), 48h (No data for +S9)	○	4)
UDS	Human/VA-4	Min (?)(+S9)	○	5)

AM	Sal	Max ( 5.0 mg/plate, ±S9)	□	1 )
CA	CHL/IU	Max ( 12 mg/ml, ±S9), 6-18h	□	2)
SM	V79/8AG	Min (?)	○	3)
DLv	Rats/ Wistar	Max ( 20 mg/ml, po )	□	4)

AM	Sal	Max ( 5.0 mg/plate, ±S9）	□	1)
CA	CHL/IU	Min ( 0.025 mg/ml, -S9）, 24h (also poly); D20= 0.05; TR= 270	○	2)

AM	Sal.	Max ( 0.5 mg/ml, ±S9)	□	1, 2)
MLA	L5178Y	Max ( 0.00125 mg/ml, ±S9)	□	3)
DLv	Mice	Max ( ? )	□	4)