E-2

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

Group E-2 化学構造　(Chemical Structure)

● Ester gum (AAG) 　（エステルガム）
　　CAS: 8050-31-5　　 Food/Natural MW:

AM Sal. Max (?) □ 1)

CA CHL/IU Max ( 8.0 mg/ml, -S9), 24, 48h　(No data for + S9) □ 2)

1)　Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)

● Ethenzamide 　（エテンザマイド；　o - Ethoxybenzamide）
　　　 938-73-8　　Medicine　　 165.19

AM Sal. Max (?) □ 1)

CA CHL/IU Min ( 0.5 mg/ml, -S9), 48h (With Poly)　D20= 0.81; TR= 10 ○ 2)

1) Natl. Inst. Hygien. Sci., Tokyo ?
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)

● Ethidium bromide (Homidium bromide) （エチジウムブロマイド）
　　 1239-45-8　 Medicine　 394.31

AM Sal. Min (?) ○ 1)

CA CHL/IU Min ( 0.03 mg/ml, -S9), 24,48h 　D20= 0.042; TR= 330 ◎ 2)

MLA L5178Y Max ( 20 μg/ml, ±S9) □ 3)

1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)
3) Oberly TJ., et al., Mutation Res., 125, 291-306 (1984)

● 17-Ethinylestradiol
　　　57-63-6　　Medicine　　296.39

AM Sal. Max (?) □ 1)

CA CHL/IU Max ( 0.0037 mg/ml, -S9), 24, 48h (No data for +S9) □ 2)

1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)

● Ethionamide （エチオナマイド）
　　 536-33-4　Medicine　　 166.24

AM Sal. Max (?) □ 1)

CA CHL/IU Min ( 0.4 mg/ml, -S9), 48h (No data for +S9): D20= 0.50; TR= 18 ○ 2)

1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)

● dl -Ethionine 　（dl- エチオニン）
　　 67-24-0　　　 163.26

AM Sal. Max (?) □ 1)

CA CHL/IU Max ( 8.0 mg/ml, ±S9), 48h □ 2)

1) Natl. Inst. Hygien. Sci., Tokyo, Japan (?)
2) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vtro LIC, Tokyo (1998) (Tables in English)

● 4-Ethoxybenzenamine （4-エトキシベンゼナミン）
　　 156-43-4　Industry　 137.18

AM Sal. Max (5.0 mg/plate, ±S9) □ 1)

CA CHL/IU Min ( 0.02 mg/ml, -S9) ○ 1)

MNv Mice/BM Min ( 1.0 g/kg, po), 24h ○ 1)

1) Ministry of Health, Labour & Welfare, Japan (Ed): Tox. Test. Rep. of Environ. Chem, Vol. (1994) (Tables in English)

● Ethoxyethanol　（エトキシエタノール）（エチルブリコル；　エチルセロソルプ；　セルソルプ）　
　　　110-80-5　　Industrial/Solvent 　　 90.12

AM Sal.. Max ( 5.0 mg/plate, ±S9) □ 1)

AM Sal.. Max ( 10.0mg/plate, ±S9) □ 2)

AM Sal. Max ( 10.0mg/plate, ±S9) □ 3)

AM E. coli Max (5.0 mg/plate, ±S9) □ 1)

SM CHO Max (42 mg/plate, ±S9) □ 4)

MLA Y1578Y Min ( 4.6 mg/plate, +S9) ○w 3)

CA CHO Min ( 20 mg/plate, -S9) ○ 4)

CA CHO Min ( 9.5 mg/ml, -S9) ○ 3)

SCE CHO Min ( 9.5 mg/ml, ±S9) ○ 3)

SLRLv Drosophila Max ( 50 mg/ml, fed ) □ 5)

SLRLv Drosophila Max ( 50000 ppm, fed ) □ 3)

MNv Mice Max ( 2.1 g/kg, ip ) □ 4)

1) Shimizu H., et al., Jpn J. Indust. Health, 27, 400-419 (1985)
2) Zeiger E., et al., Environ. Mutagen., 7, 213-232 (1985)
3) US-NTP Rep. Series, No. 26, NIH Pub. No. 93-349, PB94118106 (1993)
4) Guzzie PJ., et al., Environ. Mutagen., 8, 33 (1986)
5) Valencia R., et al., Envron. Mutagen., 8, 325-348 (1985)

US-NTP Genotoxicity Screening：
○ Ames Test：　□
○ MLA Test：　□
○ CA Test with CHO Cells： ○
○ SCE Test with CHO Cells:： ○
○SLRL Test with Drosophila:　□
　　
● Ethoxyethyl acetate　(Acetic acid 2-ethoxy ethylester) （エチレングリコールモノエチルアセテート；　エチレングリコール酢酸モノエステル；セロソルプアセテート）
　　　111-15-9　　Industrial　　 132.16

AM Sal./E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

SM CHO Max ( ? ), ±S9) □ 2)

CA CHO Min ( 4.4 mg/ml, +S9) ○ 2)

SCE CHO Max ( ? ), ±S9) □ 2)

MNv Mice, BM Max ( ? ), fed) □ 2)

1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2, pp. 63 (2000) (Tables in English)
2) Environ. Mol. Mutagen., 11, Suppl. 11, 97 (1988)

● 3-Ethoxy-4-hydroxybenzaldehyde (Ethyl vanillin)
　　　121-32-4　　Industrial　　 166.18

AM Sal./ E. coli Max ( 5.0 mg/plate, ±S9) □ 1)

1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. pp, 161 (1997)(Tables in English)

● 2-Ethoxynaphthalene (Ethyl 2-naphtyl ether)
　　　93-18-5　　Industrial　　 172.23

AM Sal./ E. coli Max ( 1.25 mg/plate, ±S9) □ 1)

1) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl. 2, p.p.163 (2000)(Tables in English)

● Ethychlozate 　（フィガロン乳剤）
　　　27512-72-7　Plant Growth Agent 　 238.6

REC B. subtilis Max ( 2.0 mg/disk) □ 1)

AM Sal Max ( 5.0 mg/plate, ±S9) □ 1)

1) Nissan Kagaku/Fujisawa Yakuhinn Co.Ltd: J. Pesticide Sci., 11, 137-138 (1986) (in Japanese)

● Ethyl acetate （酢酸エチル）　
　　　141-78-6　 Food/Industry　 88.11

AM Sal. Max ( 5.0 mg/plate, ±S9) □ 1, 2, 3)

CA CHL/IU Min ( 9.0 mg/ml, -S9), 24, 48h (Weak) (No data for +S9) ○ 4)

MNv Mice Max ( 200 mg/kg x 4), ip, 24h □ 5)

１）Zeiger E., et al.: Environ. Mol. Mutagen., 19 (Suppl. 21), 2-141 (1992)
2) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
3) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), Suppl.., pp. 164 (1997) (Tables in English)
3) Ishidate MJr.(Ed.): Data Book, Chromosomal Aberration Test:LIC, Tokyo/Elsevier, Amsterdam (1988) (Tables in English)
4) Hayashi M., et al.: Fd Chem. Toxic. 26, 487-500 (1988)　　

US-NTP Genotoxicity Screening：
○ Ames Test：　□
○ MLA　Test：　□
○ SCE Test with CHO Cells:：　○
○ CA Test with CHO Cells：　□

● Ethyl acetoacetate
　　　141-97-9　 Food 　 130.14　　　

AM Sal. Max ( 25.0 mg/plate, ±S9) □ 1, 2)

CA CHL/IU Max ( 2.0 mg/ml, -S9), 24, 48h　(No data for +S9) □ 1)

1) Ishidate MJr (Ed.), Data Book of Mutagenicity Tests on Chemicals in Bacteria, LIC/Japan (1991) (Tables in English)
2) Ministry of Labour, Japan, Mutagenicity Tests of Exist. Chem. Subst., JETOC (Ed.), pp. 165 (1996) (Tables in English)
3) Sofuni T. (Ed.): Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)

● Ethyl acrylate （アクリル酸エチル）（2-プロペン酸エチル：　エトキシカルボニルエチレン）　
　　140-88-5　Industry 　 100.12

AM Sal. Max (?) □ 1,2)

AM Sal. Max ( 2.0 mg/plate, ±S9) □ 3)

MLA L5178Y Min ( 0.2 mg/ml, +S9) ○ 4)

SM CHO Max ( 0.08 mg/ml, -S9) □ 5)

CA CHL/IU Min ( 0.01 mg/ml, -S9), 24, 48h 　D20= 0.01; TR= 3200 ◎ 6)

CA CHO Min ( 0.2 mg/ml, +S9), ○ 7)

CA CHO Min ( 0.2 mg/ml, +S9), □ 5)

SCE CHO Min ( 018mg/ml, +S9), ○v 7)

DNA L5178Y Max ( 0.03 mg/ml, -S9) □ 8)

YM S. cerevisiae Min ( 0.73 mg/ml, -S9), ○ 9)

CT BALB/c-3T3 Min ( 0.012 mg/ml, -S9), ○ 10)

SLRL Drosophila Max ( 40000 ppm ) □ 11)

MNv Mice, BM Min ( 900 mg/kg x 2, ip ) ○ 12)

MNv Mice, BM Max ( 812 mg/kg x 2, ip ) □ 13, 14)

MNv Mice, spleen Max ( 1.0 g/kg , ip ) □ 15)

SCEv Mice, spleen Max ( 1.0 g/kg , ip ) □ 15)

DNAv Rats, forestomach Max (?), or □ 16)

DNAv Rats, liver Max ( 0.4 g/kg ), or □ 17)

１）Ｈａｗｏｒｔｈ S., et al.:Environ. Mutagen., 5 (Supp. 1), 3-142 (1983)
2) Zeiger E., et al.: Environ. Mol. Mutagen, 19, (Suppl. 21). 2-141 (1992)
3) Waegemackers TH & Bensink MP., Mutation Res., 137, 95-102 (1984)
4) McGregor DB., et al., Environ. Mol. Mutagen., 12, 85-154 (1988)
5) Moore MM., et al., Mutagenesis, 6, 77-85 (1991)
6) Ishidate MJr., (ed.) Data Book of Chromosomal Aberration Tests In Vitro, LIC/ Tokyo, Elsevier/the Netherland (1988);
Sofuni T (Ed.) Data Book of Chromosomal Aberration Test In Vitro LIC, Tokyo (1998) (Tables in English)
7) Loveday KS., et al., Environ. Mol. Mutagen., 16 , 272-303 (1990)
8) Ciaccio PJ., et al., Toxicol. Sci., 46, 324-332
9) Zimmermann FK & Mohr A., Mutation Res., 270, 151-166 (1992)
10) Matthews EJ., et al., Environ. Health Perspect., 101, Suppl., 2, 347-482 (1993)
11) Valencia R., et al.: Envirn. Mutagen., 7, 325-348 (1985)
12) Perybojewska B., et al., Mutation Res., 135, 189-191 (1984)
13) Ashby J. et al., Mutagenesis, 4, 283-285 (1989)
14) Hara T., et al., Mutation Res., Commun., 16, 211-215 (1994)
15) Kligerman AD., et al., Mutagenesis, 6, 137-141 (1991)
16) Morimoto K., et al., Carcinogenesis, 12, 703-708 (1991)
17) Ghanayem BI., et al.: Fund. Appl. Toxicol., 9, 389-391 (1987)

US-NTP Genotoxicity Screening：
○ Ames Test：　○w
○ MLA Test：　○
○ SCE Test with CHO Cells:：　○w
○ CA Test with CHO Cells：　○
○ SLRL Test with Drosophila：　□
　　　　　
IARC Carcinogenicity criteria：　
　Group B2 （Probable human carcinogen）

●Top Page　（トップページ）

●Abbreviation 　（省略記号）　

●Mutagenicity Testing　（変異原性試験）

●Test Systems　(試験法の種類）

●Technical Problems　（技術的問題点）

●List of　Compounds（化合物リスト）

●Evaluation of Results　（試験結果の評価）

AM	Sal.	Max (?)	□	1)
CA	CHL/IU	Max ( 8.0 mg/ml, -S9), 24, 48h　(No data for + S9)	□	2)

AM	Sal.	Min (?)	○	1)
CA	CHL/IU	Min ( 0.03 mg/ml, -S9), 24,48h 　D20= 0.042; TR= 330	◎	2)
MLA	L5178Y	Max ( 20 μg/ml, ±S9)	□	3)

AM	Sal.	Max (5.0 mg/plate, ±S9)	□	1)
CA	CHL/IU	Min ( 0.02 mg/ml, -S9)	○	1)
MNv	Mice/BM	Min ( 1.0 g/kg, po), 24h	○	1)

AM	Sal..	Max ( 5.0 mg/plate, ±S9)	□	1)
AM	Sal..	Max ( 10.0mg/plate, ±S9)	□	2)
AM	Sal.	Max ( 10.0mg/plate, ±S9)	□	3)
AM	E. coli	Max (5.0 mg/plate, ±S9)	□	1)
SM	CHO	Max (42 mg/plate, ±S9)	□	4)
MLA	Y1578Y	Min ( 4.6 mg/plate, +S9)	○w	3)
CA	CHO	Min ( 20 mg/plate, -S9)	○	4)
CA	CHO	Min ( 9.5 mg/ml, -S9)	○	3)
SCE	CHO	Min ( 9.5 mg/ml, ±S9)	○	3)
SLRLv	Drosophila	Max ( 50 mg/ml, fed )	□	5)
SLRLv	Drosophila	Max ( 50000 ppm, fed )	□	3)
MNv	Mice	Max ( 2.1 g/kg, ip )	□	4)

AM	Sal./E. coli	Max ( 5.0 mg/plate, ±S9)	□	1)
SM	CHO	Max ( ? ), ±S9)	□	2)
CA	CHO	Min ( 4.4 mg/ml, +S9)	○	2)
SCE	CHO	Max ( ? ), ±S9)	□	2)
MNv	Mice, BM	Max ( ? ), fed)	□	2)

REC	B. subtilis	Max ( 2.0 mg/disk)	□	1)
AM	Sal	Max ( 5.0 mg/plate, ±S9)	□	1)

AM	Sal.	Max ( 5.0 mg/plate, ±S9)	□	1, 2, 3)
CA	CHL/IU	Min ( 9.0 mg/ml, -S9), 24, 48h (Weak) (No data for +S9)	○	4)
MNv	Mice	Max ( 200 mg/kg x 4), ip, 24h	□	5)

AM	Sal.	Max ( 25.0 mg/plate, ±S9)	□	1, 2)
CA	CHL/IU	Max ( 2.0 mg/ml, -S9), 24, 48h　(No data for +S9)	□	1)

AM	Sal.	Max (?)	□	1,2)
AM	Sal.	Max ( 2.0 mg/plate, ±S9)	□	3)
MLA	L5178Y	Min ( 0.2 mg/ml, +S9)	○	4)
SM	CHO	Max ( 0.08 mg/ml, -S9)	□	5)
CA	CHL/IU	Min ( 0.01 mg/ml, -S9), 24, 48h 　D20= 0.01; TR= 3200	◎	6)
CA	CHO	Min ( 0.2 mg/ml, +S9),	○	7)
CA	CHO	Min ( 0.2 mg/ml, +S9),	□	5)
SCE	CHO	Min ( 018mg/ml, +S9),	○v	7)
DNA	L5178Y	Max ( 0.03 mg/ml, -S9)	□	8)
YM	S. cerevisiae	Min ( 0.73 mg/ml, -S9),	○	9)
CT	BALB/c-3T3	Min ( 0.012 mg/ml, -S9),	○	10)
SLRL	Drosophila	Max ( 40000 ppm )	□	11)
MNv	Mice, BM	Min ( 900 mg/kg x 2, ip )	○	12)
MNv	Mice, BM	Max ( 812 mg/kg x 2, ip )	□	13, 14)
MNv	Mice, spleen	Max ( 1.0 g/kg , ip )	□	15)
SCEv	Mice, spleen	Max ( 1.0 g/kg , ip )	□	15)
DNAv	Rats, forestomach	Max (?), or	□	16)
DNAv	Rats, liver	Max ( 0.4 g/kg ), or	□	17)